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Acanthamoebic keratitis (AK) is a sight-threatening infectious keratitis caused by Acanthamoeba. Timely and appropriate conservative treatment of AK can lead to a cure of the keratitis with good visual acuity, without the need for keratoplasty in the further course of the disease. In treatment-resistant cases, keratoplasty after intensive anti-amoebic therapy (AAT), so-called "low-load keratoplasty", appears to offer a better overall prognosis and earlier visual and psychological rehabilitation than actively delayed keratoplasty (optical/therapeutic). Further studies directly comparing early and delayed keratoplasty are needed to even better determine the optimal timing of corneal transplantation in AK.
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http://dx.doi.org/10.1055/a-2558-8878 | DOI Listing |
Exp Mol Pathol
September 2025
Azienda Sanitaria Locale di Salerno, 84124 Salerno, Italy.
Cystinosis is a autosomal recessive lysosomal storage disorder caused by mutations in the CTNS gene, which encodes cystinosin, a cystine transporter. The defective function of cystinosin leads to cystine accumulation in the lysosome, resulting in progressive multi-organ damage. Cystinosis manifests early in life, with nephropathic cystinosis typically presenting in infancy with renal Fanconi syndrome, leading to chronic kidney disease and end-stage renal disease if untreated.
View Article and Find Full Text PDFCureus
July 2025
Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Fungal keratitis is a rare but severe complication following penetrating keratoplasty (PKP). We report the clinical course, rapid deterioration, and management of a case of keratitis occurring three months after PKP. A 69-year-old woman with Fuchs' endothelial dystrophy developed pseudophakic bullous keratopathy following cataract surgery.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Ophthalmology, Hadassah University Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
This study evaluated the therapeutic potential of topical Ripasudil hydrochloride hydrate in managing various forms of corneal edema. This retrospective study included 96 patients of 72.20 ± 10.
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