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We report a case of a 19-year-old diagnosed with anti-NMDAR encephalitis in relation to an immature ovarian teratoma. Ultimately, chemotherapy resulted in her improvement despite poor performance status. We provide a literature review of the published cases of anti-NMDAR encephalitis caused by immature teratomas and summarize their treatment.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163227 | PMC |
http://dx.doi.org/10.1155/crog/9923415 | DOI Listing |
Hum Reprod
September 2025
Boston IVF-IVIRMA Global Research Alliance, Waltham, MA, USA.
Study Question: Does a high proportion of immature oocytes impact embryo development and live birth rates in IVF-ICSI cycles?
Summary Answer: While a high proportion of immature oocytes is associated with lower blastocyst formation and reduced preimplantation genetic testing for aneuploidy (PGT-A) utilization, live birth rates remain comparable when key confounders-such as age, BMI, gonadotropin dosage, and metaphase-II (MII) count-are balanced, but cycles with a very low MII proportion resulted in fewer embryo transfers, which is quantitatively limiting, even if embryo quality appears unaffected.
What Is Known Already: Previous studies have linked a lower proportion of mature oocytes (MII) to decreased fertilization rates, abnormal embryo development, and lower pregnancy and live birth rates. However, it remains unclear whether these outcomes are due to quantitative limitations (fewer mature oocytes available) or qualitative deficiencies (intrinsic oocyte quality issues).
Radiol Case Rep
November 2025
Department of Radiology, Mother-Child, Faculty of Medicine and Pharmacy of Rabat, Children's Hospital, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
Malignant ovarian germ cell tumors are rare in the pediatric population, particularly in children under ten years of age. We report a unique case of a mixed germ cell tumor, comprising dysgerminoma, mature and immature teratomas, and yolk sac tumor, located on an ectopic ovary, which was discovered following adnexal torsion in a 9-year-old girl with a family history of gynecological cancers. Mixed germ cell tumors present significant diagnostic challenges due to their heterogeneous histological composition and complex biological behavior.
View Article and Find Full Text PDFJ Clin Med
August 2025
Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, 566 Nonhyeon-ro, Gangnam-gu, Seoul 06135, Republic of Korea.
The aim of this study was to determine the age-specific characteristics of ovarian teratoma and associated malignancies. This retrospective single-centre cohort study included 2181 women with ovarian teratoma who underwent surgery at our institution between January 2008 and April 2019. Malignancies associated with ovarian teratoma were divided into immature teratoma, combined ovarian malignancy, and malignant transformation of mature cystic teratoma.
View Article and Find Full Text PDFBiomolecules
August 2025
Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892-1892, USA.
The human Poly ADP-ribose Polymerase (PARP) family comprises 17 enzymes responsible for the transfer of ADP-ribose to proteins, forming poly- or mono-ADP-ribosylation. This post-translational modification regulates DNA repair and programmed cell death, processes affecting cancer biology. PARP inhibitors, including the FDA-approved olaparib, are used to treat BRCA-dependent breast and ovarian cancers.
View Article and Find Full Text PDFZygote
August 2025
Laboratory of Cellular Ultrastructure, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.
In this study, we describe the ovarian structure and oogenesis up to the final maturation of oocytes of Hypancistrus seideli. A total of sixty females were used for gonadal analysis and subsequently submitted to light and scanning electron microscopy analyses. Four maturation stages were defined: immature, maturing, mature, and spawned.
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