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Breast cancer stands as a critical health challenge for women worldwide, whose numbers continue to increase because of multiple complicating elements. The distribution of high-dimensional medical datasets creates an essential challenge for breast cancer diagnosis because it leads to reduced predictive model efficiency. This research develops an advanced version of the differential evolution (DE), named ensemble mutation and multi-population-driven differential evolution (EMMDE), for optimal feature selection. EMMDE unites multiple novel mechanisms that include population division and ensemble mutation rules, together with a time-varied geometrically diversified scheme to enhance the diversity in the population. The Gaussian binning approach creates a new guiding vector that enters the mutation rule to strike an equilibrium between exploration and exploitation, which promotes fast convergence and diverse population states. The first stage of the EMMDE testing employs standard and complex benchmark functions from the IEEE CEC2017 benchmark set, which demonstrates its outperform search ability. Later, the transfer function-based binary version is developed and validated over 10 benchmark datasets from the UCI repository and 4 datasets of breast cancer. Based on MCE and other performance metrics, it is experimentally verified that the proposed binary EMMDE algorithm achieves highly accurate and promising results for the feature selection problem. Comparison with 12 well-known and recent metaheuristics has demonstrated the impact of proposed strategies in dealing with diverse categories of numerical optimization and feature selection problems.
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http://dx.doi.org/10.1016/j.compbiomed.2025.110495 | DOI Listing |
Circ Cardiovasc Interv
September 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (F.T., G.A., M.G., K.S., D.D., G.S., M.C.).
Mitral regurgitation is the most common valve disease worldwide. Despite its wide success in inoperable or high-risk surgical patients, transcatheter edge-to-edge repair remains limited by some anatomic features and the not negligible rate of significant residual regurgitation. Transcatheter mitral valve replacement has emerged as a viable alternative that promises to overcome these issues, but its development has been progressing slowly.
View Article and Find Full Text PDFEur J Case Rep Intern Med
September 2025
Department of Internal Medicine, Hospital Universitario San Agustín, Asturias, Spain.
Background: Although splenomegaly is a common finding in Epstein-Barr virus (EBV) infection, splenic infarction is rarely reported and may be under-recognised, especially in adults. Neurological complications such as aseptic meningitis are also uncommon but documented. The simultaneous occurrence of both complications in the context of primary EBV infection is exceptional.
View Article and Find Full Text PDFFront Oncol
August 2025
Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
Purpose: Identifying radiomics features that help predict whether glioblastoma patients are prone to developing epilepsy may contribute to an improvement of preventive treatment and a better understanding of the underlying pathophysiology.
Materials And Methods: In this retrospective study, 3-T MRI data of 451 pretreatment glioblastoma patients (mean age: 61.2 ± 11.
RSC Adv
September 2025
Process and Environmental Engineering Laboratory (LIPE), Faculty of Chemistry, University of Science and Technology of Oran Mohamed Boudiaf P. O. Box 1503, El Mnaouer 31000 Oran Algeria.
In this contribution, Molecular Electron Density Theory (MEDT) is employed to investigate the (3 + 2) cycloaddition reaction between ()--methyl--(2-furyl)-nitrone 1 and but-2-ynedioic acid 2. DFT calculations at the M06-2X-D3/6-311+G(d,p) level of theory under solvent-free conditions at room temperature show that this reaction proceeds CA3-Z diastereoselectivity, with the formation of the CA3-Z cycloadduct being both thermodynamically and kinetically more favoured than the CA4-Z one. Reactivity parameters obtained from CDFT calculations reveal that compound 1 predominantly behaves as a nucleophile with moderate electrophilic features, in contrast to compound 2, which demonstrates strong electrophilicity and limited nucleophilic ability.
View Article and Find Full Text PDFRSC Chem Biol
September 2025
Department of Medicine, Perelman School of Medicine, University of Pennsylvania Philadelphia PA USA.
The bacterial DNA damage (SOS) response promotes DNA repair, DNA damage tolerance, and survival in the setting of genotoxic stress, including stress induced by antibiotics. In , translesion DNA synthesis can be fulfilled by Y-family DNA polymerases, including DNA polymerase IV (DinB). DinB features a more open active site and lacks proofreading ability, promoting error-prone replication.
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