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Article Abstract
Background: Neoadjuvant chemotherapy (NACT) improves oncologic and cosmetic outcomes in breast cancer (BC), yet recurrence remains a concern. This study identifies factors associated with recurrence at 3 and 5 years in BC patients receiving NACT.
Methods: A retrospective analysis of 933 stage I - III BC patients (2014-2021) evaluated event-free survival (EFS) predictors using multivariate analyses.
Results: Lower 5-year EFS was linked to axillary staging (cN, < 0.001), molecular subtype ( < 0.001), surgery type ( = 0.030), and post-surgical nodal status (ypN, = 0.005). High recurrence risk was observed with aggressive tumor biology, advanced disease, and residual nodal burden, while favorable responses correlated with better outcomes.
Conclusion: Biological and clinical factors guide post-NACT strategies to reduce recurrence in high-risk BC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239801 | PMC |
| http://dx.doi.org/10.1080/14796694.2025.2516410 | DOI Listing |
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