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We present a detailed characterization of a hybrid photonic platform for robust and broadly tunable ultraviolet (UV) laser generation using Čerenkov nonlinear frequency conversion (CNFC). By integrating silicon nitride waveguides with barium borate (BBO) cladding, the platform achieves UV emission across an unprecedented wavelength range of 204-319 nm. Compared to state-of-the-art UV photonic devices, our approach addresses longstanding challenges in spectral range, tunability, and integration. Theoretical modeling and experimental validation demonstrate remarkable fabrication tolerance, maintaining phase matching over a 1500 nm waveguide width variation. Angle-resolved far-field mapping reveals key trade-offs in waveguide design and emission profile. These findings offer a compact, scalable solution addressing critical needs in disinfection, quantum technologies, and free-space optical communication.
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http://dx.doi.org/10.1364/OE.553404 | DOI Listing |
Br J Haematol
September 2025
Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first-line therapy, are limited by toxicity and resistance without robust T-cell immunity. We evaluated third-party donor (TPD)-derived CMV-specific T cells (CMVSTs) as a treatment option.
View Article and Find Full Text PDFClin Investig Arterioscler
September 2025
Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-059 Lublin, Poland. Electronic address:
Background: Although aggressive low-density lipoprotein cholesterol (LDL-C) reduction has demonstrated significant cardiovascular benefits, concerns have emerged regarding potential adverse effects of very low LDL-C on cellular functions, particularly membrane integrity as cholesterol constitutes an essential component of cellular membranes. The phase angle (PhA), derived from bioelectrical impedance analysis (BIA) reflects cellular membranes integrity and nutritional status. The MALIPID study aimed to assess if LDL-C levels are associated with PhA in high cardiovascular risk patients.
View Article and Find Full Text PDFVaccine
September 2025
Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Background: Covid-19 vaccines are updated to match circulating strains based on reasoning that better strain-matched immunogenicity should provide better protection. Randomized evidence with disease endpoints to support strain matching is lacking. We evaluated COVID-19 incidence among adults randomized to a second booster of Prototype or Omicron-based vaccines.
View Article and Find Full Text PDFBiomaterials
September 2025
Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. Electronic address:
Contrary to the traditional strengthening route by adding multiple & high-dosage alloying elements, we here explored extremely compositional and phase-constituent "simplification" in rare earth (RE) containing biodegradable magnesium alloys for better biocompatibility. An ultra-lean Mg-0.1Pr alloy with a multiscale microstructure has been developed through casting and extrusion, which showed well-balanced performances that match the commercial Mg-based orthopedic products.
View Article and Find Full Text PDFPhys Rev Lett
August 2025
Brookhaven National Laboratory (BNL), Upton, New York 11973, USA.
This Letter presents an investigation of low-energy electron-neutrino interactions in the Fermilab Booster Neutrino Beam by the MicroBooNE experiment, motivated by the excess of electron-neutrino-like events observed by the MiniBooNE experiment. This is the first measurement to use data from all five years of operation of the MicroBooNE experiment, corresponding to an exposure of 1.11×10^{21} protons on target, a 70% increase on past results.
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