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Background: Sinus sequestration, well discussed in transcatheter aortic valve (TAV)-in-TAV, may also occur in TAV-in-surgical aortic valve (SAV), and its risk may be underrecognized if not assessed properly. We report an optimized TAV-in-SAV procedure in a patient at risk for sinus sequestration who was successfully treated after detailed computed tomography (CT) planning.
Case Summary: An 85-year-old woman who underwent previous surgical aortic valve replacement (Magna #19 valve, Edwards Lifesciences) presented with severe bioprosthetic stenosis. A TAV-in-SAV procedure was planned using an Evolut FX 23-mm valve (Medtronic) with optimization using a 20-mm balloon, which corresponds to the in vitro waist diameter of the Evolut FX 23-mm valve. Preprocedural CT, including maximum intensity projection (MIP) images, indicated a risk for sinus sequestration. A thorough CT assessment performed on the basis of this plan led to a successful optimized procedure.
Discussion: Identifying sinus sequestration risk is crucial in TAV-in-SAV. MIP images on CT may help visualize the relationship between the neoskirt and the sinotubular junction. Optimizing TAV expansion is essential, and CT assessment should be conducted on the basis of the planned procedure.
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http://dx.doi.org/10.1016/j.jaccas.2025.103614 | DOI Listing |
JACC Case Rep
July 2025
University Department of Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany. Electronic address:
We herein describe 2 cases of subclinical delayed coronary obstruction following transcatheter aortic valve replacement. Two female patients (74 and 83 years of age) were admitted to our department with acute heart failure due to severe valvular dysfunction of the transcatheter heart valves (THVs), which had been implanted 38 and 24 months earlier (ACURATE neo). During THV explantation and surgical aortic valve replacement, a massive circumferential endothelial growth around the upper crown of the THV prostheses was observed, leading to sequestration of the sinus of Valsalva with subclinical delayed coronary ostial obstruction.
View Article and Find Full Text PDFJACC Case Rep
August 2025
Department of Cardiovascular Medicine, East Carolina University, Greenville, North Carolina, USA.
Background: The Lotus valve is a mechanically expanded transcatheter heart valve with design features that pose challenges for valve-in-valve transcatheter aortic valve replacement (ViV-TAVR). Performing BASILICA (bioprosthetic or native aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction during TAVR) to modify the Lotus leaflets has only been reported in benchtop models.
First-in-human/early Reports Summary: A 79-year-old woman with a degenerated 23-mm Lotus transcatheter heart valve and high risk of coronary occlusion underwent BASILICA, followed by implantation of a 26-mm Evolut FX valve.
Catheter Cardiovasc Interv
September 2025
Department of Cardiology, Instituto de investigación imas12, 12 de Octubre University Hospital, Madrid, Spain.
TAVR embolization and coronary occlusion are two rare but potentially fatal complications which may require operators to conduct an urgent valve retrieval using a snare. Moreover, implantation of a second valve is sometimes necessary to ensure a first inadequate position, which increases the risk of coronary occlusion due to sinus sequestration. We present the case of an 85-year-old patient who suffered a cardiac arrest due to massive aortic regurgitation after partial proximal embolization of a first TAVR.
View Article and Find Full Text PDFJACC Cardiovasc Interv
August 2025
Division of Cardiology, University of Washington Medical Center, Seattle, Washington, USA.
JACC Case Rep
June 2025
Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
Background: Sinus sequestration, well discussed in transcatheter aortic valve (TAV)-in-TAV, may also occur in TAV-in-surgical aortic valve (SAV), and its risk may be underrecognized if not assessed properly. We report an optimized TAV-in-SAV procedure in a patient at risk for sinus sequestration who was successfully treated after detailed computed tomography (CT) planning.
Case Summary: An 85-year-old woman who underwent previous surgical aortic valve replacement (Magna #19 valve, Edwards Lifesciences) presented with severe bioprosthetic stenosis.