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Patients with lower extremity orthopedic trauma are at increased risk of venous thromboembolism (VTE). American College of Surgeons data revealed that a New York Level 2 Trauma Center administered unfractionated heparin (UFH) four times more often, and low molecular weight heparin (LMWH) two-and-a-half times less often, than national averages, despite institutional and national guidelines supporting use of LMWH over UFH. We retrospectively reviewed VTE prophylaxis practices in adult patients with lower extremity orthopedic trauma at the institution to identify trends and/or aberrant administration. Pearson chi-square tests of independence were utilized to determine significance. Approximately 57.3% received no preoperative VTE prophylaxis, whereas 32.8% received UFH and 9.1% received LMWH. Unfractionated heparin was administered at greater or equal frequency than LMWH within each age, sex, and diagnosis group. Patients admitted to general surgical units received UFH more frequently than those admitted to orthopedics. A multimodal intervention can be used to change current practices and improve care quality.
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http://dx.doi.org/10.1097/JHQ.0000000000000485 | DOI Listing |
Foot Ankle Int
September 2025
Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), University Hospital, LMU Munich, Germany.
Background: Despite considerable improvements in surgical treatment strategies for unstable ankle fractures, long-term follow-up studies on conventional treatment strategies are missing. The aim of the study was to assess the patient-reported long-term outcome (≥15 years) following surgically treated ankle fractures.
Methods: Retrospective, single-center, outcome study with a current follow-up.
Ugeskr Laeger
September 2025
fdeling for Led- og Knoglekirurgi, Københavns Universitetshospital - Herlev og Gentofte Hospital.
The clinical presentation of rotator cuff ruptures varies greatly and ranges from no symptoms to severe shoulder impairment. Clinical shoulder tests are an effective screening tool to identify patients who require early specialist assessment or further radiological investigation, but they are not sufficient to rule out smaller ruptures. Small ruptures can often be managed non-surgically, while larger traumatic ruptures may necessitate early surgical intervention.
View Article and Find Full Text PDFACS Nano
September 2025
School of Medicine, Nankai University, Tianjin 300071, China.
In situ articular cartilage (AC) regeneration is a meticulously coordinated process. Microfracture has been the most extensive clinical approach in AC repair, but it faces challenges such as matrix degradation, generation, and remodeling within a local inflammatory microenvironment. So far, it remains a challenge to establish a multistage regulatory framework for coordinating these cellular events, particularly the immune response and chondrocyte proliferation in microfracture-mediated AC repair microenvironments, which is crucial for promoting AC regeneration quality.
View Article and Find Full Text PDFBone Jt Open
September 2025
School of Medicine, University of Nottingham, Nottingham, UK.
Aims: The number of hip fractures is increasing, with significant mortality and morbidity, particularly among frail and comorbid patients. Enhanced recovery after surgery (ERAS) pathways have proven effective in elective orthopaedics, but this has not been investigated in people with hip fractures. This study aimed to identify current perioperative practice and develop a cohesive ERAS pathway tailored for hip fracture patients, to standardize and optimize care.
View Article and Find Full Text PDFExp Cell Res
September 2025
Department of Microsurgery, Orthopedic Trauma and Hand Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:
Promoting lymphatic vessel regeneration is an important method for repairing lymphedema. SOX18 can regulate lymphatic vessel development and plays a crucial role in promoting lymphatic vessel generation. This study aims to demonstrate the role of SOX18 in regulating lymphatic vessel regeneration for the repair of lymphedema and explore its related molecular mechanism.
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