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We developed and examined the performance of a two-stage random-effects meta-analysis estimator for synthesizing published estimates of the value per statistical life (VSL). The meta-estimation approach accommodates unbalanced panels with one or multiple observations from each independent group of primary estimates, and distinguishes between sampling and non-sampling sources of error, both within and between groups. We used Monte Carlo simulation experiments to test the performance of the meta-estimator on constructed datasets. Simulation results indicate that, when applied to datasets of modest size, the approach performs best when the within-group non-sampling error variances are assumed to be homogeneous among groups. This allows for two levels of non-sampling errors while preserving degrees of freedom and therefore increasing statistical efficiency. Simulation results also show that the estimator compares favorably to several other commonly used meta-analysis estimators, including other two-stage estimators. As a demonstration, we applied the approach to a pre-existing meta-dataset including 113 VSL estimates assembled from 10 revealed preference and 9 stated preference studies conducted in the U.S. and published between 1999 and 2019.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165433 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0324630 | PLOS |
BMC Public Health
September 2025
Department of Epidemiology and Biostatistics, School of Public Health, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
Background: Influenza poses a significant threat to public health, potentially influenced by environmental factors. However, the role of meteorological factors (MFs) on influenza risks in China remains underexplored. This study explored the effect of MFs on laboratory-confirmed influenza (LCI) cases in Anhui, China.
View Article and Find Full Text PDFEnviron Int
August 2025
Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Background: Heatwaves are becoming more frequent and intense in a warming climate and can cause substantial excess deaths. This study aimed to assess and map heatwave-related mortality burdens across Australia.
Methods: Heatwaves were defined as periods of ≥2 consecutive days with daily mean temperatures above the 95th percentile for each community (SA2 or SA3 level) during 2009-2019.
Clin Trials
August 2025
Dana Farber Cancer Institute, Boston, MA, USA.
Background/aim: Basket designs have been utilized in recent oncology clinical trials due to an increased interest in precision medicine. One current successful basket trial is the American Society for Clinical Oncology Targeted Agent and Profiling Utilization Registry (TAPUR) study, a pragmatic phase II trial where patients are matched based on their tumor genomic profile to treatments that target specific genomic alterations. Despite its success, recruiting patients with rare genomic alterations remains challenging.
View Article and Find Full Text PDFClin Oral Implants Res
August 2025
Clinic for Reconstructive Dentistry, University of Zurich, Zurich, Switzerland.
Objectives: This systematic review aimed to determine whether patient-reported outcomes (PROs) are associated with clinician-reported outcomes (ClinROs) in terms of esthetics in patients with single implant-supported crowns in the esthetic region.
Methods: A systematic electronic search was conducted following a pre-established protocol to identify randomized controlled trials (RCT) involving patients with single implant-supported crowns in the esthetic region. Studies had to assess both patient- and clinician-reported outcomes.
BMJ Public Health
August 2025
MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Objectives: Interventions for obesity that require individual behaviour change, such as behavioural weight management interventions, may contribute to health inequalities. We explored if there was evidence of inequalities in the attendance at and effectiveness of behavioural weight management interventions in adults.
Design: Two-stage individual participant data meta-analysis.