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Introduction: Despite the focus on pediatric social needs, there is a dearth of research on financial strain, which is characterized by challenges in meeting basic needs. This study systematically reviewed the literature on different measures of self-reported financial strain and health outcomes.
Methods: A systematic literature search in PubMed, PsychINFO, and Web of Science identified papers that examined relationships between self-reported financial strain and health outcomes among U.S. children or adolescents. Two blinded reviewers screened each paper (65 papers, 39 studies) and extracted data. Financial strain measures were coded for content. Findings were synthesized based on age and type of measure.
Results: Financial strain measures asked about the lack of money for basic needs (32 studies), difficulty making ends meet (23 studies), relying on coping strategies (13 studies), experiencing stress or worry about finances (4 studies) anticipating future strain (4 studies), and the lack of money for leisure (4 studies). Financial strain was associated with poorer health and well-being and more behavior challenges among children of all ages, poorer academic performance among school-age children, and more depressive symptoms among adolescents. Associations were consistent across diverse samples when accounting for other socioeconomic factors and across financial strain measures, including a single item about difficulty making ends meet. Fourteen studies tested hypothesized mechanistic factors that explain associations, including material, psychosocial, and behavioral pathways.
Discussion: The consistency of associations between financial strain and pediatric health and well-being highlights an urgent need to address financial strain to advance health equity. Results show predictive validity for a simple financial strain question, similar to one recommended by the National Academy of Medicine.
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http://dx.doi.org/10.1016/j.focus.2025.100337 | DOI Listing |
Front Mol Neurosci
August 2025
Department of Cardiovascular Sciences, Lewis Katz School of Medicine, Lemole Center for Integrated Lymphatics and Vascular Research, Temple University, Philadelphia, PA, United States.
Introduction: Endothelial-to-mesenchymal transition (EndoMT), cell death, and fibrosis are increasingly recognized as contributing factors to Alzheimer's disease (AD) pathology, but the underlying transcriptomic mechanisms remain poorly defined. This study aims to elucidate transcriptomic changes associated with EndoMT, diverse cell death pathways, and fibrosis in AD using the 3xTg-AD mouse model.
Methods: Using RNA-seq data and knowledge-based transcriptomic analysis on brain tissues from the 3xTg-AD mouse model of AD.
Front Genet
August 2025
College of Poultry Production and Management, TANUVAS, Hosur, India.
Background: India's indigenous sheep breeds have evolved under extreme and diverse agro-ecological pressures, yet the genomic basis of their resilience and local adaptation remains poorly understood.
Method: This study combines genomic inbreeding estimates, runs of homozygosity (ROH), population structure analyses, and composite selection scans to investigate three native Indian breeds-Changthangi, Deccani, and Garole-within a panel of nine breeds that also includes populations from Africa (Ethiopian Menz), East and South Asia (Tibetan, Chinese Merino, Bangladesh Garole, Bangladesh East), and Europe (Suffolk).
Results: ROH and heterozygosity estimates revealed strong contrasts: Bangladesh East sheep exhibited high genomic inbreeding (F≈14.
J Hosp Palliat Care
September 2025
Emergency Department, Seoul National University Hospital, Seoul, Korea.
Purpose: This study aimed to identify predictors of end-of-life (EOL) care provided by emergency nurses in South Korea.
Methods: A cross-sectional survey was conducted using a structured questionnaire. Data were collected using Google Forms between June 21 and 30, 2022.
Front Microbiol
August 2025
BioDyMIA Research Unit, Université de Lyon, Université Claude Bernard Lyon 1, ISARA Lyon, Bourg-en-Bresse, France.
Bioprotective LAB3 cells that produce bacteriocin-like substances were entrapped in 4% (w/w) sodium alginate matrices, either with or without 10% (w/w) sodium caseinate. The effects of bead formulation-alginate alone or combined with caseinate, with or without the addition of 20% (w/w) MRS broth or M17 broth-on the culturability of LAB3 cells within the beads and their anti activity were assessed over 12 days of storage at 30 °C in closed bottles. Calcium-alginate-caseinate beads supplemented with MRS broth proved most effective in preserving both culturability and anti- activity.
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August 2025
Department of Medical Laboratory Diagnostics, School of Medical Technology, Shaoyang University, Shaoyang, China.
is an environmental opportunistic fungal pathogen, which can lead to invasive aspergillosis in immunocompromised individuals, and resistant to conventional antifungual agents has become a growing concern. This study investigated the antifungal activity and the molecular antifungal mechanisms of Cinnamaldehyde (CA) against , specifically its impact on metabolic pathways and protein metabolism. In susceptibility tests, CA was found to exhibit promising antifungal activity against in both solid and liquid culture (biomass) systems, with the minimum inhibitory concentration (MIC) determined as 40-80 μg/mL.
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