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Numerous estimation procedures employed in causal inference often rely on accurately measured data. However, the prevalence of measurement errors in practical studies may yield biased effect estimates. It is common to employ validation samples to rectify such biases in the measurement error literature. This article focuses on the estimation of the average causal effect with a misclassified binary treatment in a primary population of interest. By leveraging a validation sample with covariates, an error-prone version of treatment and a true treatment recorded, we provide identifiability results under certain conditions. Building on identifiability, we explore three classes of estimators, each demonstrating consistency and asymptotic normality within distinct model sets. Furthermore, we propose a multiply robust estimation approach for the treatment effect based on the semiparametric theory framework. The multiply robust estimator retains consistent under any one of the listed model sets and achieves the semiparametric efficiency bound, provided all models are correct. We demonstrate the satisfactory performance of the proposed estimators through simulation studies and a real data analysis.
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http://dx.doi.org/10.1177/09622802251338364 | DOI Listing |
J Biopharm Stat
August 2025
Department of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, China.
Propensity score-integrated Bayesian dynamic borrowing methods offer an effective approach for covariate adjustment when using external data to augment randomized controlled trials (RCTs). However, identifying the correct propensity score model can be challenging due to unknown treatment selection processes, potentially leading to model misspecification and biased estimates. To improve robustness to model misspecification, we propose an innovative Bayesian inference procedure that incorporates multiply robust weights into the construction of informative power priors.
View Article and Find Full Text PDFInt J Emerg Med
August 2025
University of Birmingham. school of Chemical Engineering, Birmingham, UK.
Background: Climate change is disrupting the global food chain, affecting food production, delivery and safety. Extreme weather events disrupt the quality of food and water, while rising temperatures accelerate the spread of microbes. Habitat destruction also forces wildlife in close proximity to people, increasing the risk of zoonotic diseases.
View Article and Find Full Text PDFJ Virol
August 2025
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, U.S. Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Viral coinfections and their impact on long-term immunity represent an understudied area in disease ecology and infectious disease research. Coinfections can influence the host's susceptibility to future infections, alter host and pathogen population dynamics, modify infection and shedding patterns, impose evolutionary pressures, and affect the risk of zoonotic spillover. Egyptian rousette bats (ERB; ; common name: Egyptian rousettes) are a natural reservoir host for Marburg virus (MARV) and Ravn virus (RAVV), as well as a vertebrate reservoir for Kasokero virus (KASV) and a putative reservoir for Sosuga virus (SOSV).
View Article and Find Full Text PDFCan J Stat
June 2025
Department of Biostatistics, Harvard University, Boston, USA.
Large observational databases are often subject to missing data. As such, methods for causal inference must simultaneously handle confounding and missingness; surprisingly little work has been done at this intersection. Motivated by this, we propose an efficient and robust estimator of the causal average treatment effect from cohort studies when confounders are missing at random.
View Article and Find Full Text PDFMacrocyclization and multiple backbone -methylations can significantly improve the pharmacological properties of peptides. Since chemical synthesis of such compounds is often challenging, enzyme-based production platforms are an interesting option. Here, we characterized OphP, a serine peptidase involved in the cyclization of omphalotins, a group of ribosomally produced dodecapeptides with multiple backbone -methylations.
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