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Low anterior resection syndrome (LARS) is a common and often debilitating complication following sphincter-preserving surgery for rectal cancer. With evolving techniques in surgical oncology, sphincter preservation has become more prevalent; however, this has led to an increased incidence of postoperative bowel dysfunction. This narrative review explores the current understanding of LARS, including its definition, pathophysiology, clinical evaluation, treatment options, and preventive strategies. Emphasis is placed on both conservative and surgical management approaches, as well as the importance of patient education and multidisciplinary care in improving quality of life.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152706 | PMC |
http://dx.doi.org/10.7759/cureus.83942 | DOI Listing |
Skeletal Radiol
September 2025
Department of Radiology, Hospital do Coração (HCor), Rua Desembargador Eliseu Guilherme, 53, 7th floor. CEP, São Paulo, SP, 04004-03, Brazil.
Atypical proximal tibial fractures in adolescents are rare, particularly when linked to hormonal therapy for short stature. This case series reports the clinical and imaging features of atypical proximal tibial and distal femoral physeal fractures in male adolescents undergoing combined growth hormone (GH) and aromatase inhibitor (AI) therapy for idiopathic short stature. We report three cases of skeletally immature male adolescents (ages 12-16) treated with GH and anastrozole who presented with acute leg pain following low-energy trauma during soccer.
View Article and Find Full Text PDFCureus
August 2025
Faculty of Medicine, University of Costa Rica, San Jose, CRI.
This systematic review examines the potential association between semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, and the development of non-arteritic anterior ischemic optic neuropathy (NAION). Nine studies were included, consisting of retrospective cohort analyses, case series, and pharmacovigilance reports. Findings across the literature were inconsistent, with some studies reporting an increased risk while others found no significant association.
View Article and Find Full Text PDFJ Refract Surg
September 2025
Purpose: To evaluate tilt, decentration, and axial stability of the Clareon toric intraocular lens (TIOL) (CNW0T3-9; Alcon Laboratories, Inc) over a 6-month follow-up period.
Methods: A single-center, prospective, interventional clinical trial was conducted with a study population of 130 eyes from 82 patients who received a Clareon TIOL. Tilt, decentration, and the aqueous depth were determined preoperatively and at 1 week and 6 months postoperatively using anterior segment optical coherence tomography (Casia 2; Tomey Corporation).
Knee Surg Sports Traumatol Arthrosc
September 2025
Clinique du sport, Paris, France.
Purpose: To compare the outcomes of isolated anterior cruciate ligament reconstruction (ACLR) versus ACLR + lateral extra-articular procedures (LEAPs) at mid-term follow-up in a low activity population based on the Tegner activity scale (TAS ≤ 4).
Methods: This was a retrospective analysis comparing patients with a pre-injury TAS ≤ 4 who underwent primary isolated ACLR versus ACLR + LEAPs between 2012 and 2022. Propensity score matching based on age, sex, and presence of meniscal injury was used to establish two groups: ACLR alone and ACLR with LEAP.
Aim: This study evaluated the short-term outcomes of low anterior resection for rectal cancer in Japan before and after the COVID-19 pandemic, with a particular focus on the timing of its reclassification within Japan in May 2023.
Methods: Using data from the Japanese National Clinical Database, we analyzed 109 754 low anterior resection cases between January 2018 and December 2023, categorized into pre-pandemic (February 2020 and earlier), pandemic (March 2020-April 2023), and post-pandemic (May 2023 onward) periods. Trends in the number of low anterior resection cases, postoperative intensive care unit utilization, and complications, including anastomotic leakage and pneumonia, were examined.