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http://dx.doi.org/10.1177/10806032251346693 | DOI Listing |
Acta Anaesthesiol Scand
October 2025
Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Background: Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro- and anti-inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Methods: In this secondary, explorative analysis of a prospective single-centre cohort (n = 459), we assessed associations between endotheliopathy biomarkers (syndecan-1, soluble thrombomodulin (sTM), platelet endothelial cell adhesion molecule-1 (PECAM-1)) and inflammatory biomarkers (pro-inflammatory: IFN-ϒ, IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF-α; anti-inflammatory: IL-4, IL-10, IL-13) at ICU admission using linear regression.
Microbiol Spectr
September 2025
USDA, Agricultural Research Service, Southern Regional Research Center, New Orleans, Louisiana, USA.
With increasing antibiotic resistance and the paucity of new antibiotics in the development pipeline, exploration of antimicrobial peptide applications alone or in combination with existing antibiotics is more crucial than ever. The recent study by J. Varin-Simon, E.
View Article and Find Full Text PDFAnn Hepatol
September 2025
Department of Hepatobiliary Surgery, Inner Mongolia Xing'an Meng People's Hospital, Xing 'an League, Inner Mongolia Autonomous Region, 137400, China. Electronic address:
Reg Anesth Pain Med
September 2025
Department of Anesthesiology and Reanimation, Ondokuz Mayis University Faculty of Medicine, Samsun, Türkiye
Lancet Microbe
September 2025
Centre for Clinical Microbiology, Division of Infection and Immunity, University College London, London, UK; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London NW3 OPQ, UK. Electronic address: