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Article Abstract
Background: Mass spectrometry imaging (MSI) has emerged as a powerful tool for the spatial visualization of biomolecules, driving advances in diverse fields such as biomedical research, plant metabolomics, and forensic science. Incorporating nanostructures, particularly metallic and metal oxide nanoparticles, has revolutionized laser desorption/ionization (LDI)-MSI by enhancing ionization efficiency, spatial resolution, and sensitivity.
Results: This review focuses on the preparation, application, and performance of various metallic nanostructures (e.g., gold, silver, platinum, and metal oxides) in LDI-MSI, emphasizing both fundamental physicochemical properties and their role in improving sensitivity, spatial resolution, and data reproducibility.
Significance: We provide a comparative assessment of metallic nanostructures versus other types of nanomaterials (quantum dots, carbon-based materials), highlight key advantages and current limitations, and offer a roadmap for future developments in nanomaterial-assisted MSI, including prospective strategies for stabilizing and functionalizing surfaces, exploring alternative laser wavelengths, and ensuring robust analytical workflows.
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| http://dx.doi.org/10.1016/j.aca.2025.344256 | DOI Listing |
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