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Article Abstract
Background: In addition to nodal lesions, over 30% of mantle cell lymphomas (MCLs) also have gastrointestinal involvement, characteristically presenting as multiple lymphomatous polyposis (MLP), which rarely involve the esophagus. Most related papers have been case reports, and no comprehensive studies have been conducted; thus, the actual clinical situation has remained unknown for a long time.
Aim: To elucidate the actual clinical situation of esophageal involvement of MCL presenting with MLP, including its prognosis.
Methods: From January 2001 to December 2021, among MCL patients whose gastrointestinal lesions were histopathologically confirmed by endoscopic biopsy at our center, 6 patients with MLP in the esophagus were selected. We retrospectively examined the clinical features of these patients, including their prognosis.
Results: In all patients, multiple lesions were present in the gastrointestinal tract other than the esophagus and in the lymph nodes throughout the body, and most patients also had lesions involving the bone marrow or spleen. Most of the treatments include chemotherapy, with a 50% survival period of less than 2 years and a 5-year survival rate of approximately 30%, indicating a poor prognosis.
Conclusion: Patients with esophageal involvement of the MCL who presented with MLP had a large tumor burden and poor survival.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142258 | PMC |
| http://dx.doi.org/10.4251/wjgo.v17.i5.105448 | DOI Listing |
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