98%
921
2 minutes
20
Carcinoembryonic antigen (CEA) is a tumor marker most often associated with colorectal cancer, but elevated levels may also indicate other malignancies, including lung cancer. Although not recommended as a standalone screening or diagnostic tool, persistent elevation in CEA levels may warrant further investigation. This case report describes a 71-year-old woman who was found to have progressively rising CEA levels during routine private health screening despite being asymptomatic. Initial workup, including colonoscopy, revealed no evidence of colorectal malignancy. However, further evaluation prompted by new respiratory symptoms and imaging findings led to the diagnosis of Stage IVa lung adenocarcinoma. This case underscores the importance of a comprehensive diagnostic approach in patients with unexplained tumor marker elevation. It highlights the potential role of primary care in identifying atypical presentations of serious conditions.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12145215 | PMC |
http://dx.doi.org/10.7759/cureus.83751 | DOI Listing |
JCI Insight
September 2025
Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute, and.
Steroid-refractory gut acute graft-versus-host disease (SR-Gut-aGVHD) is the major cause of nonrelapse death after allogeneic hematopoietic cell transplantation. High numbers of donor-type IL-22+ T cells, IL-22-dependent dysbiosis, and loss of antiinflammatory CX3CR1hi mononuclear phagocytes (MNPs) play critical roles in SR-Gut-aGVHD pathogenesis. CEACAM1 on intestinal epithelial cells (IECs) is proposed to regulate bacterial translocation and subsequent immune responses in the intestine.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of General Surgery, Beijing Tongren Hospital, Beijing, China.
This study investigates the clinical value of plasma Septin-9 gene methylation (mSEPT9) and carcinoembryonic antigen (CEA) in colorectal cancer (CRC), and their correlations with clinicopathological features and recurrence. A retrospective study included 81 CRC patients (observation group) and 73 healthy controls (comparison group) from January 2021 to January 2023, with pathological diagnosis as the gold standard. Plasma mSEPT9 (via quantitative PCR) and CEA (via electrochemiluminescence) levels were measured.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Al Jahra Hospital, Al Jahra, KWT.
Carcinoembryonic antigen (CEA) is a commonly used tumor marker, primarily for the surveillance of colorectal and other gastrointestinal malignancies. However, its diagnostic specificity is limited, as CEA levels may be elevated in several benign conditions. This case report aims to highlight the potential diagnostic confusion and psychological distress caused by incidental CEA elevation in asymptomatic individuals when tested outside of an appropriate clinical context.
View Article and Find Full Text PDFCureus
August 2025
Department of Obstetrics and Gynecology, University of Ioannina, Ioannina, GRC.
A 34-year-old nulligravida with schizophrenia presented after four months of progressive abdominal distension, culminating in severe respiratory compromise. An urgent transabdominal ultrasound was initially interpreted as massive ascites; however, its diagnostic accuracy was limited by the extreme abdominal distension and the patient's inability to change position due to respiratory distress. Further evaluation with CT of the thorax and abdomen revealed a 35 × 42 × 48.
View Article and Find Full Text PDFWorld J Clin Oncol
August 2025
Department of Oncologic Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Background: Gastric signet ring cell carcinoma (SRCC) is a rare, aggressive subtype of gastric cancer characterized by poor prognosis and distinctive biological behavior. Despite advances in gastric cancer treatment, SRCC remains difficult to diagnose early and manage effectively due to its infiltrative pattern and molecular variability. Reliable prognostic markers are critical to guide clinical management.
View Article and Find Full Text PDF