Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
MicroRNAs (miRNAs) are non-coding and internally derived small RNA molecules. They post-transcriptionally direct gene expression either by inhibiting translation or initiating degradation of mRNA. Conserved evolutionarily, these miRNAs have a significant role in several developmental and regulatory functions in organisms including mammalian cell growth, differentiation, and apoptosis. An individual miRNA can modulate a network of mRNA expression by binding to multiple mRNAs through imperfect sequence complementarity. In several types of cancer, dysregulation of miRNAs may contribute to cell initiation, migration, incursion, proliferation, immortality, and drug resistance. Among all leukemia cases, approximately 15 % of patients suffer from chronic myeloid leukemia (CML). miRNA-based modulation offers the idiosyncratic competence for regulating a variety of genes simultaneously; in that way, it could help to modulate accordant signalling pathways that are engaged in cell differentiation, proliferation, and survival. The one-drug, one-target approach thereby evolves into a paradigm of one drug with multiple targets. This review will delve into the understanding of miRNA dysregulation and recent advancements in therapeutic strategies based on miRNAs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbcan.2025.189366 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Anti-Leukemic Potential of Curcumin in Chronic Myeloid Leukemia: A Systematic Review of In Vitro Studies.
Food Sci Nutr
September 2025
Department of Nutrition Sciences, School of Health Larestan University of Medical Sciences Iran.
Chronic myeloid leukemia (CML), a myeloproliferative neoplasm, is characterized by the fusion gene, which results in constitutive tyrosine kinase activity. While tyrosine kinase inhibitors (TKIs) have significantly improved CML outcomes, resistance and the persistence of leukemic stem cells remain major clinical challenges. Curcumin, a natural polyphenol derived from , has demonstrated potential anticancer properties.
View Article and Find Full Text PDFRole of Toll-Like Receptors in Myeloid Neoplasms: Focuses on the Molecular Mechanisms and Clinical Impact on Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myeloid Leukemia.
APMIS
September 2025
Cancer Cytogenomic Laboratory, Center for Research and Drug Development (NPDM), Federal University of Ceara, Fortaleza, Ceara, Brazil.
Toll-like receptors (TLRs) are essential components of the innate immune system, functioning as pattern recognition receptors (PRRs) to detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). In hematological malignancies, particularly myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), and chronic myeloid leukemia (CML), TLRs influence inflammation, disease progression, and therapeutic response. This review highlights the prognostic relevance of TLR expression, the role of the MyD88 signaling pathway in clonal evolution, and the dual nature of TLR-mediated immune responses, either promoting antitumor activity or contributing to leukemogenesis.
View Article and Find Full Text PDFAn old leukaemia in young patients-Genetic characteristics of paediatric chronic myeloid leukaemia.
Br J Haematol
September 2025
Department of Pediatrics, Stanford University, Stanford, California, USA.
Chronic myeloid leukaemia (CML) accounts for 2% of leukaemias in children and 9% in adolescents. While the BCR::ABL1 fusion gene remains a hallmark across all age groups, emerging evidence suggests that paediatric CML exhibits unique biological and clinical characteristics compared to its adult counterpart. Children often present with more aggressive clinical features and show distinct treatment response patterns.
View Article and Find Full Text PDFExpression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells.
PLoS Biol
September 2025
Department of Virology, Immunology & Microbiology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, United States of America.
Despite the success of antiretroviral therapy in suppressing plasma viremia in people living with human immunodeficiency virus type-1 (HIV-1), persistent viral RNA expression in tissue reservoirs is observed and can contribute to HIV-1-induced immunopathology and comorbidities. Infection of long-lived innate immune cells, such as tissue-resident macrophages and microglia may contribute to persistent viral RNA production and chronic inflammation. We recently reported that de novo cytoplasmic expression of HIV-1 intron-containing RNA (icRNA) in macrophages and microglia leads to MDA5 and MAVS-dependent innate immune sensing and induction of type I IFN responses, demonstrating that HIV icRNA is a pathogen-associated molecular pattern (PAMP).
View Article and Find Full Text PDFThe immune receptor SLAMF5 regulates myeloid-cell mediated neuroinflammation in multiple sclerosis.
PLoS Biol
September 2025
Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.
Multiple sclerosis (MS) is a chronic neurological disorder characterized by demyelination of the central nervous system (CNS), leading to a broad spectrum of physical and cognitive impairments. Myeloid cells within the CNS, including microglia and border-associated macrophages, play a central role in the neuroinflammatory processes associated with MS. Activation of these cells contributes to the local inflammatory response and promotes the recruitment of additional immune cells into the CNS.
View Article and Find Full Text PDF