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Neurological conditions, including dementia, pose a major public health challenge, contributing to a significant and growing clinical, economic, and societal burden. Traditionally, research and clinical practice have focused on diseases like dementia in isolation. However, in an ageing, multimorbid population, this approach is becoming increasingly inadequate. Recognising brain health as a lifelong attribute influenced by various health determinants, this paper explores the concept of brain health, identifies key challenges in assessing it effectively, and examines how digital biomarkers could provide a versatile measurement framework to enhance monitoring and facilitate earlier intervention. Finally, we outline future directions to help advance definitions of meaningful aspects of brain health integration, and practical adoption of digital biomarkers, enhancing our capacity to measure and preserve ‘brain health capital’ or ‘brain span’ across the lifecourse.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141678 | PMC |
http://dx.doi.org/10.1038/s41746-025-01675-2 | DOI Listing |
Neurology
September 2011
Banner Alzheimer's Institute, 901 E Willetta Street, Phoenix, AZ 85006, USA.
Arch Gen Psychiatry
August 2011
Banner Alzheimer's Institute, 901 E Willetta St., Phoenix, AZ 85006, USA.
Arch Neurol
October 2011
Division of Epidemiology, University of California, Berkeley, 94720-3190, USA.
Objective: To delineate the trajectories of Aβ42 level in cerebrospinal fluid (CSF), fludeoxyglucose F18 (FDG) uptake using positron emission tomography, and hippocampal volume using magnetic resonance imaging and their relative associations with cognitive change at different stages in aging and Alzheimer disease (AD).
Design: Cohort study.
Setting: The 59 study sites for the Alzheimer's Disease Neuroimaging Initiative.