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Background: The COVID-19 pandemic substantially impacted mental health. This study explored age-related differences in the mental health and wellbeing of participants during the initial wave of the COVID-19 pandemic.
Methods: Secondary analyses of data from 21,106 participants collected between July and December 2020 across 152 countries was conducted. Multivariable logistic regression models were used to determine the relationship between the dependent variables and age after accounting for potential confounders. The dependent variables examined were emotional distress, social isolation, sleep pattern changes, sexual activity changes, financial security, housing and food insecurity, changes in family relationships, memory complaints, and post-traumatic stress syndrome (PTSS). Age groups were considered: young adults (18-24), adults (25-49), and older individuals (≥50). The confounding variables were sociodemographic variables namely: sex (male or female), marital status (single or has had a relationship), employment status (employed, unemployed, student, or retiree), educational status (none, primary, secondary, or college/university), country of residence income (low-income countries, lower-middle-income countries, upper-middle-income countries, and high-income countries) and pandemic stringency index indicating the comprehensiveness of pandemic policies adopted at country level.
Results: Of the 21,106 participants, 12,807 (60.7%) were aged 25-49. Compared to those over 50, 18-24-year-olds had significantly higher odds of increased sexual activity (AOR: 4.41), housing insecurity (AOR: 1.73), and PTSD (AOR: 3.22), but lower odds of social isolation (AOR: 0.66), food insecurity (AOR: 0.85), and memory complaints (AOR: 0.53). Similarly, 25-49-year-olds had higher odds of increased sexual activity (AOR: 2.65), housing insecurity (AOR: 2.28), food insecurity (AOR: 1.14), worsened family relationships (AOR: 1.15), and PTSD (AOR: 2.24), but lower odds of social isolation (AOR: 0.84), sleep disturbances (AOR: 0.82), and memory complaints (AOR: 0.81). Emotional distress and financial insecurity did not differ significantly across age groups.
Conclusion: The study highlights age-specific variations in mental health challenges during the pandemic. The nuanced impact of age on mental wellbeing emphasizes the need for targeted interventions. Future research should explore the interplay between age, pandemic-related factors, and specific mental health outcomes to inform tailored support mechanisms for diverse age groups.
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http://dx.doi.org/10.3389/fpubh.2025.1550719 | DOI Listing |
Eat Disord
September 2025
Center for Eating and feeding Disorders Research (CEDaR), Psychiatric Center Ballerup, Mental Health Services in the Capital Region of Denmark.
Proc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
J Gambl Stud
September 2025
Department of Psychology and Azrieli Israel Center for Addiction and Mental Health, The Hebrew University of Jerusalem, Jerusalem, Israel.
Research suggests that Problem Gambling (PG) may result from maladaptive emotional regulation strategies aimed at escaping emotions and stress caused by negative life events and trauma. The current study, aimed to examine the effect of exposure to the mass trauma of October 7, 2023 terror attack and the consequent Swords of Iron war in Israel, and difficulties in emotional regulation on PG. We utilized longitudinal data of self-reports in the Problem Gambling Severity Index collected before the terror attack (April 2022) and during the Swords of Iron war (December 2023, March 2024, June 2024; N = 899) from a large sample of adult Jewish Israelis.
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