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http://dx.doi.org/10.1002/hem3.70156 | DOI Listing |
Hemasphere
June 2025
Sorbonne University, Service de Médecine Interne Hôpital Saint-Antoine, AP-HP Paris France.
Introduction: The efficacy of erythropoiesis-stimulating agents (ESAs) for transfusion-dependent (TD) anemia in lower-risk myelodysplastic syndromes (LR-MDS) is limited. Luspatercept achieved significantly greater rates of red blood cell (RBC) transfusion independence (TI) versus epoetin alfa (an ESA) in the phase 3 COMMANDS trial. This analysis assessed long-term RBC-TI, cumulative response, and safety with luspatercept in COMMANDS.
View Article and Find Full Text PDFBMJ
August 2013
Department of Intensive Care Medicine, Royal Perth Hospital, Perth, Western Australia 6000.
Objectives: To evaluate the efficacy and safety of intravenous iron, focusing primarily on its effects on haemoglobin, requirement for transfusion, and risk of infection.
Design: Systematic review and meta-analysis of randomised controlled trials investigating the safety and efficacy of intravenous iron therapy.
Data Sources: Randomised controlled trials from Medline, Embase, and the Cochrane Central Register of Controlled Trials from 1966 to June 2013, with no language restrictions.