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Article Abstract
Total synthesis and determination of absolute configuration of colletotrichumolide and its 3-diastereomer have been achieved by Julia-Kociennski olefination, Shiina lactonization, chemo- and regioselective epoxide opening, and Mitsunobu reaction as key steps. Synthesized compounds (-) were tested for their antibacterial activity against two of the most resilient bacterial strains, and , and they were found to show significant antibacterial activity against and cell lines.
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