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Rationale And Objectives: The aim of this study was to evaluate image quality for contrast-enhanced (CE) neck MRI with a deep learning-reconstructed VIBE sequence with acceleration factors (AF) 4 (DL4-VIBE) and 6 (DL6-VIBE).
Methods: Patients referred for neck MRI were examined in a 3-Tesla scanner in this prospective, single-center study. Four CE fat-saturated (FS) VIBE sequences were acquired in each patient: Star-VIBE (4:01 min), VIBE (2:05 min), DL4-VIBE (0:24 min), DL6-VIBE (0:17 min). Image quality was evaluated by three radiologists with a 5-point Likert scale and included overall image quality, muscle contour delineation, conspicuity of mucosa and pharyngeal musculature, FS uniformity, and motion artifacts. Objective image quality was assessed with signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and quantification of metal artifacts.
Results: 68 patients (60.3% male; mean age 57.4±16 years) were included in this study. DL4-VIBE was superior for overall image quality, delineation of muscle contours, differentiation of mucosa and pharyngeal musculature, vascular delineation, and motion artifacts. Notably, DL4-VIBE exhibited exceptional FS uniformity (p<0.001). SNR and CNR were superior for DL4-VIBE compared to all other sequences (p<0.001). Metal artifacts were least pronounced in the standard VIBE, followed by DL4-VIBE (p<0.001). Although DL6-VIBE was inferior to DL4-VIBE, it demonstrated improved FS homogeneity, delineation of pharyngeal mucosa, and CNR compared to Star-VIBE and VIBE.
Conclusion: DL4-VIBE significantly improves image quality for CE neck MRI with a fraction of the scan time of conventional sequences.
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http://dx.doi.org/10.1016/j.acra.2025.05.020 | DOI Listing |
J Magn Reson Imaging
September 2025
Department of Neurology, Dell Medical School, University of Texas at Austin, Austin, Texas, USA.
Background: Cerebrovascular reactivity reflects changes in cerebral blood flow in response to an acute stimulus and is reflective of the brain's ability to match blood flow to demand. Functional MRI with a breath-hold task can be used to elicit this vasoactive response, but data validity hinges on subject compliance. Determining breath-hold compliance often requires external monitoring equipment.
View Article and Find Full Text PDFElectrophoresis
September 2025
Therapeutics Development and Supply-Analytical Development, Janssen Research & Development, LLC, Malvern, Pennsylvania, USA.
Monoclonal antibodies (mAbs) present analytical challenges due to their inherent heterogeneity and susceptibility to post-translational modifications (PTMs) during production and storage. Monitoring of charge heterogeneity profiles by imaged capillary isoelectric focusing (icIEF) has been aided by the use of non-detergent sulfobetaines (NDSBs), particularly NDSB-211, to enhance protein solubility and stability. When used in a quality control laboratory setting, NDSB-211 has shown performance variability over time due to residual manufacturing impurities that impact the capillary isoelectric focusing separation.
View Article and Find Full Text PDFJ Marital Fam Ther
October 2025
Department of Dynamic and Clinical Psychology, and Health Studies, Sapienza University of Rome, Rome, Italy.
This systematic review and meta-analysis examines the role of romantic attachment as a protective or risk factor in how individuals cope with infertility diagnosis, treatment, and outcomes. A systematic search was conducted across six databases from January 1, 2011, to February 3, 2025. Seventeen studies met inclusion criteria, exploring associations between romantic attachment and individual psychological correlates of infertility.
View Article and Find Full Text PDFNihon Hoshasen Gijutsu Gakkai Zasshi
September 2025
Division of Neonatology, Maternal and Perinatal Center, Toyama University Hospital.
Purpose: This study aimed to evaluate whether low-dose CT imaging using an Sn filter can provide image quality sufficient for the differential diagnosis of cranial deformities in infants while maintaining an effective dose comparable to that of conventional radiography.
Methods: We calculated the effective dose for both head X-ray imaging and low-dose CT with an Sn filter. Phantom images acquired using a CT scanner equipped with an Sn filter were evaluated for bone suture visibility at various conditions (from 10 mAs to 50 mAs, every 10 mAs) using a 4-point visual grading scale.
Brachytherapy
September 2025
Department of Radiological Sciences, School of Health Sciences, Fukushima Medical University, 10-6 Sakaemachi, Fukushima, Fukushima, 960-8516, Japan.
Purpose: This study presents the dose-based intra-preplan (DIP) method for intracavitary/interstitial brachytherapy (IC/ISBT) in cervical cancer, optimizing catheter configurations based on dose distribution. This study aimed to assess the DIP method's clinical feasibility and efficacy.
Methods And Materials: The DIP method incorporates the implant modeling function and the hybrid inverse planning optimization algorithm in Oncentra Brachy.