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An acridine unit entangled into a macrocyclic derivative forms a very efficient fluorophore featuring the confinements of a 7.6.6 defect. The designed and unoccupied internal cavity in the significantly rigidified environment changes the optical properties, serving as a switch between on and off states. The observed behaviour unequivocally confirms a dominating influence of the hydrogen-like interaction for quenching the emission properties within organic chromophores.
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http://dx.doi.org/10.1039/d5cc01126d | DOI Listing |
J Cancer Res Ther
September 2025
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Sichuan, China.
Objectives: To compare the effects of different adjuvant treatments for different pathological types of early-stage cervical cancer post-surgery.
Materials And Methods: Patients with International Federation of Gynecology and Obstetrics (FIGO) stages I-II squamous cell carcinoma (SCC), adenocarcinoma (ADC), and adenosquamous carcinoma (ASC) who underwent hysterectomy and postoperative radiotherapy (RT) from 2004 to 2015 in the surveillance, epidemiology, and end results program database were analyzed. The clinicopathological characteristics and survival rates were compared.
Proc Inst Mech Eng H
August 2025
IDMEC, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Augmented techniques in the reverse total shoulder arthroplasty (rTSA) have emerged to treat large asymmetric glenoid bone defects and restore shoulder function. However, whether metallic wedge-augmented (W-AUG-rTSA) and angled bony increased-offset (angled BIO-rTSA) rTSA techniques provide equivalent implant fixation remains unclear. This study aimed to directly compare the initial fixation of W-AUG-rTSA and angled BIO-rTSA in a 15° retroverted glenoid, while also assessing the impact of graft stiffness and the number of peripheral screws.
View Article and Find Full Text PDFFront Pharmacol
June 2025
Department of Anesthesiology, Shandong Provincial Third Hospital, Jinan, Shandong, China.
Objective: Defective in cullin neddylation 1 (DCN1) plays a pivotal role in anticardiac fibrosis by interacting with UBC12 and catalyzing cullin neddylation, which activates cullin-RING E3 ligases (CRLs). As a key modulator of anticardiac fibrosis, DCN1 has emerged as an attractive target for therapeutic intervention. The aim of this study is to design and evaluate novel DCN1 inhibitors using a combination of three-dimensional quantitative structure-activity relationship (3D-QSAR) modeling, molecular docking, and molecular dynamics simulations.
View Article and Find Full Text PDFNutrients
June 2025
Department of Medicine, Veterans Affairs Medical Center, Providence, RI 02908, USA.
Objectives: To investigate the relationship between serum magnesium levels, prescribed oral magnesium replacement, and major adverse cardiovascular events (MACE) in type-2 diabetes mellitus (T2D).
Research Design And Methods: This nationwide retrospective study analyzed 1,284,940 US Veterans (≥18 years) with T2D who had outpatient serum magnesium testing between 1999-2021 in the Veterans Health Administration. The relationship between serum magnesium levels and MACE (hospitalizations for acute myocardial infarction, heart failure, ischemic stroke, or all-cause mortality) was determined using multivariable-adjusted Cox-regression models.
Cureus
May 2025
General Surgery, NRI Medical College & General Hospital, Vijayawada, IND.
Background Incisional hernias are a frequent complication following abdominal surgeries, significantly contributing to morbidity. Surgical repair using mesh placement has become the standard of care, with ongoing debates regarding the optimal anatomical plane for mesh placement. Even though the retrorectus plane advocated by Rives and Stoppa has become the choice of plane for most surgeons, it is not without recurrence.
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