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Abstract: The SS-520-3 sounding rocket was launched on November 4th, 2021 as part of the Grand Challenge Initiative - Cusp from Ny-Ålesund, Svalbard. The rocket was launched into the cusp ionosphere during the main phase of a geomagnetic storm. In this study we utilize two low energy particle analyzers as well as a multi-needle Langmuir probe and an impedance probe as part of the rocket payload. This study aims to provide an overview of the flight conditions from a range of ground-based instruments and scintillation receivers. We were able to confirm that the rocket entered the cusp through the poleward edge at around of northern geographic latitude. Additionally, the rocket encountered polar cap patches (PCP), as well as a patch within the cusp (CP) and a newly-formed tongue of ionisation (TOI). Analysis of the density variations within different scale sizes show enhancements within meter-size and kilometer-size scales on the edges of PCP, within the CP and TOI. Overall, the enhancements within the variations on all sizes, as well as enhancements of the electron density were significantly higher within the CP and TOI in comparison to the PCP, though all structures were encountered at similar altitudes. The strongest enhancements were found on the poleward edge of the TOI, corresponding to strong fluctuations within the electron density. The TOI also had the largest enhancements within gradients of kilometer-size in comparison to meter-sizes. As the TOI is convecting with respect to the background plasma, the edges are susceptible to instabilities like the Kelvin-Helmholtz instability (KHI) and Gradient-Drift instability (GDI), giving rise to plasma density structures on several scale sizes.
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http://dx.doi.org/10.1186/s40623-025-02189-7 | DOI Listing |
bioRxiv
August 2025
Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Mammalian female meiosis is uniquely regulated to produce a developmentally competent egg capable of supporting embryogenesis. During meiosis I, homologous chromosomes segregate, with half extruded into the first polar body. The egg then arrests at metaphase II and only resumes meiosis and extrudes the second polar body following fertilization.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
July 2025
Department of Breast, Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029, China.
Study on the mechanism of Fangxia Dihuang Formula(FXDH) in treating breast cancer complicated with depression through the regulation of M1/M2 microglial polarization via the PERK/eIF2α axis. In addition to control group and 4T1 group, a mouse model of breast cancer complicated with depression was established using 4T1 cells combined with corticosterone. The mice were divided into model group, PERK/eIF2α signaling axis agonist(CCT020312, 2 mg·kg~(-1)·d~(-1)) group, CCT020312(2 mg·kg~(-1)·d~(-1)) + FXDH(13.
View Article and Find Full Text PDFACS Nano
September 2025
Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR 999077, P. R. China.
Osteoarthritis (OA) remains a formidable clinical challenge due to the intricate interplay of cartilage degradation, synovitis, and subchondral bone remodeling. Clinical intra-articular therapies are hindered by rapid drug clearance, inadequate cartilage penetration, and a lack of strategies targeting multifactorial pathogenesis. Herein, we engineered a hybrid nanoplatform for multiaction therapeutics by integrating boundary lubrication and "osteochondral-synovial synergistic effect.
View Article and Find Full Text PDFMaterials (Basel)
August 2025
Programa de Pós-Graduação em Ciência da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil.
This study investigates a novel approach based on micro-pulse plasma electrolytic oxidation (μPPEO), aiming to improve the control over key parameters such as the Ca/P ratio, the formation of anatase and rutile phases, and the porosity of titanium surfaces-factors that are critical for enhancing bioactivity. By employing electrical micro-pulses with widths of 50 μs or 100 μs, our aim was to restrict the discharge time and subsequent surface/electrolyte reactions. The results demonstrate that μPPEO-treated surfaces exhibit uniform pore diameters, a Ca/P ratio of approximately 1.
View Article and Find Full Text PDFJ Fungi (Basel)
August 2025
Departamento de Microbiología, Centro de Investigación Científica y de Educación Superior de Ensenada (CICESE), Ensenada 22860, B.C., Mexico.
Endocytosis in filamentous fungi is spatially restricted to a subapical zone known as the endocytic collar, which plays essential roles in membrane recycling and the maintenance of polarized growth. In this study, we investigated the ontogeny of the endocytic collar in by tracking fimbrin-labeled endocytic patches using confocal microscopy during conidial germination, hyphal branching, and regeneration following mechanical injury. We consistently observed an initial accumulation of endocytic patches at the hyphal tip, forming an apical cap, which later reorganized into a subapical collar.
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