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The agricultural sector faces significant challenges from weed-induced crop losses, driving increased herbicide use and associated environmental and health risks. Controlled-release formulations (CRFs) of herbicides offer a promising solution by employing advanced materials such as synthetic and natural polymers, clay minerals, siliceous materials, and nanoparticles to optimize the release and efficacy of active ingredients (AIs). This review explores the mechanisms of controlled release - desorption, diffusion, osmosis, and matrix dissolution - and examines the role of carrier properties in modulating AI release kinetics. Advances in smart nanocarriers and encapsulation technologies demonstrate improved precision, reduced herbicide usage, and minimal impact on soil microbiomes, fostering sustainable agriculture. Despite these innovations, challenges remain in standardizing processes, enhancing cost-effectiveness, and scaling up field applications. This study emphasizes the critical balance between improving agricultural productivity and minimizing ecological harm, highlighting the potential of CRFs to revolutionize weed management practices while preserving soil health and ecosystem integrity.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117858 | PMC |
http://dx.doi.org/10.1080/15685551.2025.2508142 | DOI Listing |
Int J Pharm
September 2025
Department of Veterinary Medicine, Central Animal Facility, Amrita Institute of Medical Sciences and Research Centre, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, Kerala 682041, India.
The clinical use of gemcitabine (GEM), a frontline chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC), is limited by its short half-life, rapid systemic clearance, associated dose-limiting toxicities and a faster development of resistance in pancreatic cancer. Aspirin (ASP), a repurposed NSAID, has been shown to sensitize PDAC cells to GEM through modulation of multiple oncogenic and inflammatory pathways. However, its clinical use is restricted by dose-dependent gastrointestinal toxicity.
View Article and Find Full Text PDFAppl Biochem Biotechnol
September 2025
Programa de Engenharia Química/COPPE, Universidade Federal do Rio de Janeiro, Cidade Universitária, 21941-972, Rio de Janeiro, Brazil.
Polymer particles, including synthetic polymers such as poly(methyl methacrylate) (PMMA) and poly(styrene-co-divinylbenzene) (P(S-co-DVB)) beads, have been widely used as enzymatic supports and drug carriers. In this sense, it is important to understand the stabilization or degradation of such polymer matrices under specific chemical and enzymatic media. For this reason, the present work aims to evaluate the current status and prospects of treatments of PMMA and P(S-co-DVB) particles intended for biotechnological and biomedical applications under basic, acidic, and enzymatic environments.
View Article and Find Full Text PDFDrug Dev Ind Pharm
September 2025
Department of Pharmaceutics, Mallige College of Pharmacy, Silvepura, Bangalore -560090.
ObjectivesThis review aims to explore gelling drug delivery systems with emphasis on formulation strategies, gelation mechanisms, administration routes, and therapeutic benefits. It also seeks to understand the role of different polymers in achieving optimal gelation and drug release profiles. Additionally, the review aims to identify current research gaps and highlight potential areas for future development and clinical translation.
View Article and Find Full Text PDFClin Exp Dent Res
October 2025
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Objective: Through a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials.
Material And Methods: The systematic approach involved searches in the PubMed/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Objectives: To synthesize a temperature-responsive multimodal motion microrobot (MMMR) using temperature and magnetic field-assisted microfluidic droplet technology to achieve targeted drug delivery and controlled drug release.
Methods: Microfluidic droplet technology was utilized to synthesize the MMMR by mixing gelatin with magnetic microparticles. The microrobot possessed a magnetic anisotropy structure to allow its navigation and targeted drug release by controlling the temperature field and magnetic field.