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http://dx.doi.org/10.1016/j.jacc.2025.04.029 | DOI Listing |
J Am Coll Cardiol
August 2025
NewAmsterdam Pharma, Amsterdam, the Netherlands.
Background: The cholesteryl ester transfer protein inhibitor obicetrapib decreases levels of atherogenic lipids and raises high-density lipoprotein cholesterol (HDL-C).
Objectives: In this study, we sought to determine the effect of obicetrapib on cardiovascular events.
Methods: The effects of 10 mg obicetrapib and placebo daily on major adverse cardiovascular event (MACE) rates were investigated in a pooled analysis of 354 patients with heterozygous familial hypercholesterolemia (HeFH) and 2,530 patients with atherosclerotic cardiovascular disease (ASCVD) over 365 days.
Am J Cardiovasc Drugs
August 2025
Richmond University Medical Center/Mount Sinai, Staten Island, NY, USA.
Despite the well-established benefits of statin therapy in reducing atherosclerotic cardiovascular disease (ASCVD) risk, many patients fail to achieve recommended low-density lipoprotein cholesterol (LDL-C) targets or experience statin intolerance, necessitating alternative approaches. This review examines advances in non-statin lipid-lowering therapies, focusing on proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors (monoclonal antibodies and inclisiran), bempedoic acid, and other non-statin lipid medications. We evaluate their mechanisms of action, clinical efficacy, and safety profiles on the basis of landmark trials.
View Article and Find Full Text PDFCardiovasc Res
August 2025
Elucida Research, Beverly, MA, USA.
Aims: Elevated Lp(a) levels increase cardiovascular (CV) risk. Lp(a) contains oxidized phospholipids that may promote lipid oxidation more than other lipoproteins. The highly unsaturated omega-3 fatty acid EPA has multiple double bonds that can trap free radicals in resonance structures.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
August 2025
The First Clinical College, The First Afiliated Hospital of Jinan University, Guangzhou, China.
Background: Limited evidence supports the use of electronic health records for developing prediction models to identify high-risk plaques in patients with unstable angina pectoris (UAP). This study aimed to develop and validate a practical high-risk plaque prediction model in patients with new onset UAP.
Methods: We prospectively enrolled consecutive patients presenting with new-onset UAP who underwent both coronary angiography and coronary computed tomography angiography (CCTA) at our center from January 2021 to December 2021.
Prog Cardiovasc Dis
August 2025
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India; Applied Biomedical Research Center, Basic Sciences Resear
Introduction: Pregnancy induces significant metabolic changes, including altered lipid profiles, yet the role of lipoprotein(a) [Lp(a)] remains unclear. While Lp(a) levels rise during pregnancy and may be linked to complications like pre-eclampsia and gestational diabetes, existing studies show inconsistent findings. This meta-analysis aims to investigate Lp(a) levels in normal and high-risk pregnancy and its associated outcomes.
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