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To advance the hydrogen energy-driven low-altitude aviation sector, it is imperative to establish sophisticated risk assessment frameworks tailored for hydrogen-powered aircraft. Such methodologies will deliver fundamental guidelines for the preliminary design phase of onboard hydrogen systems by leveraging rigorous risk quantification and scenario-based analytical models to ensure operational safety and regulatory compliance. In this context, this study proposes a comprehensive hazard and operability analysis-fuzzy dynamic Bayesian network (HAZOP-FDBN) framework, which quantifies risk without relying on historical data. This framework systematically maps the risk factor relationships identified in HAZOP results into a dynamic Bayesian network (DBN) graphical structure, showcasing the risk propagation paths between subsystems. Expert knowledge is processed using a similarity aggregation method to generate fuzzy probabilities, which are then integrated into the FDBN model to construct a risk factor relationship network. A case study on low-altitude aircraft hydrogen storage systems demonstrates the framework's ability to (1) visualize time-dependent failure propagation mechanisms through bidirectional probabilistic reasoning, and (2) quantify likelihood distributions of system-level risks triggered by component failures. Results validate the predictive capability of the model in capturing emergent risk patterns arising from subsystem interactions under low-altitude operational constraints, thereby providing critical support for safety design optimization in the absence of historical failure data.
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http://dx.doi.org/10.3390/s25103075 | DOI Listing |
Psychol Res Behav Manag
September 2025
Department of Internal Medicine, Shaoxing Second Hospital, Shaoxing City, Zhejiang Province, People's Republic of China.
Background: Sleep quality has emerged as a critical public health concern, yet our understanding of how multiple determinants interact to influence sleep outcomes remains limited. This study employed partial correlation network analysis to examine the hierarchical structure of sleep quality determinants among Chinese adults.
Methods: We investigated the interrelationships among nine key factors: daily activity rhythm, social interaction frequency, work-life balance, light exposure, physical activity level, time control perception, shift work, weekend catch-up sleep, and sleep quality using the extended Bayesian Information Criterion (EBIC) glasso model.
Exp Dermatol
September 2025
L'Oréal Research and Innovation, Aulnay sous Bois, France.
As hyperpigmentation can worsen with exposure to ultraviolet (UV) and visible light (VL), sunscreens with well-balanced UVB/UVA protection and VL-blocking pigments are recommended. Assessing efficiency against VL-induced pigmentation is then mandatory. Recently, an in vivo pigmentation assessment allowing a VL protection factor (pVL-PF) determination, and an in vitro predictive method based on transmittance measures were introduced.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Understanding acute infectious disease dynamics at individual and population levels is critical for informing public health preparedness and response. Serological assays, which measure a range of biomarkers relating to humoral immunity, can provide a valuable window into immune responses generated by past infections and vaccinations. However, traditional methods for interpreting serological data, such as binary seropositivity and seroconversion thresholds, often rely on heuristics that fail to account for individual variability in antibody kinetics and timing of infection, potentially leading to biased estimates of infection rates and post-exposure immune responses.
View Article and Find Full Text PDFOne Health
December 2025
U.S. Geological Survey, Eastern Ecological Science Center, Laurel, MD 20708, USA.
With the continued spread of highly pathogenic avian influenza (HPAI), understanding the complex dynamics of virus transfer at the wild - agriculture interface is paramount. Spillover events (i.e.
View Article and Find Full Text PDFJ Biotechnol
September 2025
Chemical Engineering Department, University of Waterloo, Waterloo, N2L 3G1, ON, Canada. Electronic address:
While Dynamic Flux Balance Analysis provides a powerful framework for simulating metabolic behavior, incorporating operating conditions such as pH and temperature, which profoundly impact monoclonal antibodies production, remains challenging. This study presents an advanced dFBA model that integrates kinetic constraints formulated as functions of pH and temperature to predict CHO cell metabolism under varying operational conditions. The model was validated against data from 20 fed-batch experiments conducted in Ambr®250 bioreactors.
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