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High stress and shape deviation during the glass forming process often led to low yield rates, posing a challenge in the production of high-precision smartwatch components. To address this issue, a numerical model was developed to simulate and analyze the forming behavior of 3D curved glass. The study focused on achieving a balance between energy consumption and key quality attributes, such as residual stress and shape accuracy. Results showed that forming pressure primarily affects shape deviation, while forming temperature plays a dominant role in energy usage and residual stress. Through orthogonal experiments, optimal parameters were identified: a forming temperature of 630 °C, pressure of 0.25 MPa, and cooling rate of 0.25 °C/s effectively minimize residual stress. Meanwhile, shape deviation is minimized at 630 °C, 0.30 MPa, and a cooling rate of 0.75 °C/s. Energy efficiency analysis indicated that low efficiency occurs at 610 °C with a 3 °C/s heating rate. Furthermore, NSGA-II multi-objective optimization validated the model's accuracy, with prediction errors under 20%, offering valuable guidance for the precise fabrication of smartwatch glass.
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http://dx.doi.org/10.3390/mi16050584 | DOI Listing |
Cancer Immunol Res
September 2025
The Wistar Institute, Philadelphia, PA, United States.
Ovarian cancer remains a major health threat with limited treatment options available. It is characterized by immunosuppressive tumor microenvironment (TME) maintained by tumor-associated macrophages (TAMs) hindering anti-tumor responses and immunotherapy efficacy. Here we show that targeting retinoblastoma protein (Rb) by disruption of its LxCxE cleft pocket causes preferential cell death in Rbhigh M2 polarized or M2-like Rbhigh immunosuppressive TAMs by induction of ER stress, p53 and mitochondria-related cell death pathways.
View Article and Find Full Text PDFJAACAP Open
September 2025
University of Vermont, Burlington, Vermont.
Objective: The transition to college is a period of growth and vulnerability for young adult health and well-being and provides a critical window for potential behavioral interventions. In this study, we sought to examine the trajectory of anxiety symptoms and their association with individual characteristics, exposure to stressors, and sleep behaviors during the transition to college.
Method: We recruited full-time, incoming undergraduate students at a university in the northeastern United States to participate during the first semester of college between October 21, 2022, and December 12, 2022.
Adv Pharm Bull
July 2025
Stem Cell Research Center, Tabriz University of University of Medical Sciences, Tabriz, Iran.
Purpose: Spinal cord ischemia-reperfusion injury (SCII) is initiated following the occlusion of supporting blood vessels, leading to the loss of neurological function. Here, we aimed to study the regenerative properties of tourniquet-induced hindlimb ischemia exosomes (Exos) in SCII Wistar rats.
Methods: Exos were isolated from rats following tourniquet-induced hindlimb ischemia.
Odontology
September 2025
Department of Biomaterials, Hamidiye Institute of Health Sciences, University of Health Sciences Turkey, Istanbul, Turkey.
This study evaluates the cytotoxicity, apoptosis, and expression of stress-related genes (TP53 and NF-κB) in response to gingiva-colored indirect composite resins used for veneering tooth or implant-supported prostheses or characterization of denture bases. A total of 120 disc-shaped specimens (2 mm thick, 10 mm diameter) gingiva-colored indirect composite resin specimens (Group A: Anaxgum-Anaxdent, Group B: Crealing Paste Gum-Bredent, Group G: Gradia Gum-GC, Group N: SR Nexco GUM-Ivoclar Vivadent) were prepared and divided into four groups (n = 10 per group). Surface wettability was assessed using water contact angle (WCA) measurements.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Mechanical & Industrial Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, United States.
With the rapid advancement in autonomous vehicles, 5G and future 6G communications, medical imaging, spacecraft, and stealth fighter jets, the frequency range of electromagnetic waves continues to expand, making electromagnetic interference (EMI) shielding a critical challenge for ensuring the safe operation of equipment. Although some existing EMI shielding materials offer lightweight construction, high strength, and effective shielding, they struggle to efficiently absorb broadband electromagnetic waves and mitigate dimensional instability and thermal stress caused by temperature fluctuations. These limitations significantly reduce their service life and restrict their practical applications.
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