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Purpose: To introduce MATI (Microstructural Analysis Toolbox for Imaging), a versatile MATLAB-based toolbox that combines both simulation and data fitting capabilities for microstructural dMRI research.
Methods: MATI provides a user-friendly, graphical user interface that enables researchers, including those without much programming experience, to perform advanced simulations and data analyses for microstructural MRI research. For simulation, MATI supports arbitrary microstructural tissues and pulse sequences. For data fitting, MATI supports a range of fitting methods, including traditional non-linear least squares, Bayesian approaches, machine learning, and dictionary matching methods, allowing users to tailor analyses based on specific research needs.
Results: Optimized with vectorized matrix operations and high-performance numerical libraries, MATI achieves high computational efficiency, enabling rapid simulations and data fitting on CPU and GPU hardware. While designed for microstructural dMRI, MATI's generalized framework can be extended to other imaging methods, making it a flexible and scalable tool for quantitative MRI research.
Conclusion: MATI offers a significant step toward translating advanced microstructural MRI techniques into clinical applications.
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http://dx.doi.org/10.1016/j.mri.2025.110428 | DOI Listing |
Comput Struct Biotechnol J
August 2025
Institut de Recherche en Cancérologie de Montpellier (IRCM), Équipe Labellisée Ligue Contre le Cancer, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
Digital twins (DTs) are emerging tools for simulating and optimizing therapeutic protocols in personalized nuclear medicine. In this paper, we present a modular pipeline for constructing patient-specific DTs aimed at assessing and improving dosimetry protocols in PRRT such as therapy. The pipeline integrates three components: (i) an anatomical DT, generated by registering patient CT scans with an anthropomorphic model; (ii) a functional DT, based on a physiologically-based pharmacokinetic (PBPK) model created in SimBiology; and (iii) a virtual clinical trial module using GATE to simulate particle transport, image simulation, and absorbed dose distribution.
View Article and Find Full Text PDFJ Biomed Opt
September 2025
Fraunhofer Institute for Microelectronic Circuits and Systems IMS, Duisburg, Germany.
Significance: The spatial and temporal distribution of fluorophore fractions in biological and environmental systems contains valuable information about the interactions and dynamics of these systems. To access this information, fluorophore fractions are commonly determined by means of their fluorescence emission spectrum (ES) or lifetime (LT). Combining both dimensions in temporal-spectral multiplexed data enables more accurate fraction determination while requiring advanced and fast analysis methods to handle the increased data complexity and size.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
Department of Geriatric, Chongqing Mental Health Center, 401147 Chongqing, China.
Background: The negative impact of obesity on cognitive function (CF) is well-established; nevertheless, no prior studies have explored the link between conicity index and cognitive performance. This research sought to investigate the link between conicity index and cognitive impairment.
Methods: Data were obtained from a cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014 (NHANES), with CF evaluated by the total scores of three cognitive tests (TCT), the delayed recall test (DRT), the immediate recall test (IRT), the animal fluency test (AFT), and the digit symbol substitution test (DSST).
Ultrason Imaging
September 2025
Pontificia Universidad Católica del Perú, San Miguel, Lima, Peru.
The acoustic nonlinearity parameter (B/A) could enhance the diagnostic capabilities of conventional ultrasonography and quantitative ultrasound in tissues and diseases. Nonlinear acoustic propagation theory of plane waves has been used to develop a dual-energy model of the depletion of the fundamental related to the Gol'dberg number and subsequently to the B/A of media (a reference phantom is used as a baseline). The depletion method, however, needs a priori information of the attenuation coefficient (AC) of the assessed media.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
September 2025
Department of Dyes and Chemical Engineering, Bangladesh University of Textiles, Dhaka, Bangladesh.
This study quantitatively evaluated the adsorption performance of natural bentonite for removing three dye classes-cationic (Basic dye: BEZACRYL RED GRL), anionic (Reactive dye: AVITERA LIGHT RED SE), and non-ionic (Disperse dye: BEMACRON BLUE HP3R) from synthetic textile wastewater. Batch adsorption experiments were conducted under varying conditions of contact time (15-90 min), adsorbent dosage (20-60 g L⁻), pH (4 and 12), and temperature (25-100 °C), with dye concentrations quantified by UV-Vis spectroscopy. At a contact time of 30 min and room temperature (25 °C), maximum removal efficiencies reached 99.
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