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This study explores the emerging potential of non-aqueous gels for topical therapy, examining their unique properties, diverse applications, and the challenges involved in their formulation and clinical use. By highlighting these aspects, the article aims to shed light on the future of localized drug delivery and inspire further research and innovation in this promising field. Additionally, the article addresses the critical need for regulatory considerations, stability testing, and patient acceptability. It also emphasizes the role of non-aqueous gels in revolutionizing dermatological and transdermal therapies, particularly by enhancing the stability of drugs that are hydrolyzed in the presence of water.
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http://dx.doi.org/10.2174/0126673878371228250519073422 | DOI Listing |
Recent Adv Drug Deliv Formul
May 2025
Department of Pharmaceutics, ISF College of Pharmacy, Moga-142001, Punjab, India.
This study explores the emerging potential of non-aqueous gels for topical therapy, examining their unique properties, diverse applications, and the challenges involved in their formulation and clinical use. By highlighting these aspects, the article aims to shed light on the future of localized drug delivery and inspire further research and innovation in this promising field. Additionally, the article addresses the critical need for regulatory considerations, stability testing, and patient acceptability.
View Article and Find Full Text PDFDrug Deliv Transl Res
November 2024
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
The ocular administration of lipophilic and labile drugs such as epalrestat, an aldose reductase inhibitor with potential for diabetic retinopathy treatment, demands the development of topical delivery systems capable of providing sufficient ocular bioavailability. The aim of this work was to develop non-aqueous oleogels based on soybean oil and gelators from natural and sustainable sources (ethyl cellulose, beeswax and cocoa butter) and to assess their reproducibility, safety and efficiency in epalrestat release and permeation both ex vivo and in vivo. Binary combinations of gelators at 10% w/w resulted in solid oleogels (oleorods), while single gelator oleogels at 5% w/w remained liquid at room temperature, with most of the oleogels displaying shear thinning behavior.
View Article and Find Full Text PDFGels
December 2023
Department of Chemistry "Ugo Schiff" & CSGI Consortium, University of Florence, Via della Lastruccia, 3-13, 50019 Sesto Fiorentino, Italy.
Polydimethylsiloxane (PDMS) organogel sponges were prepared and studied in order to understand the role of pore size in an elastomeric network on the ability to uptake and release organic solvents. PDMS organogel sponges have been produced according to sugar leaching techniques by adding two sugar templates of different forms and grain sizes (a sugar cube template and a powdered sugar template), in order to obtain materials differing in porosity, pore size distribution, and solvent absorption and liquid retention capability. These materials were compared to PDMS organogel slabs that do not contain pores.
View Article and Find Full Text PDFGels
July 2023
Thermal-Fluid Energy Machine Lab., Department of Mechanical Engineering, Gachon University, 1342, Seongnam-daero, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
A few drugs need non-aqueous gels for release in the specific region of the intestine. The present work focuses on preparing ,-Dimethyl acrylamide-Diallyl Maleate (DMAA-DAM) gel in Dimethyl sulfoxide (DMSO) solvent by applying different doses of gamma radiation and then characterization. The blend solution of 10%: 10%-DMAA: DAM was prepared in DMSO and irradiated at 2, 5, 10, 20, and 30 kGy doses from the Co-60 gamma source.
View Article and Find Full Text PDFGels
April 2023
Institute of Inorganic Chemistry, Department of Chemistry and Physics, Technische Universität Bergakademie Freiberg (TUBAF), Leipziger Strasse 29, 09596 Freiberg, Saxony, Germany.
Condensation reactions of chlorosilanes (SiCl and CHSiCl) and bis(trimethylsilyl)ethers of rigid, quasi-linear diols (CH)SiO--OSi(CH) ( = 4,4'-biphenylene () and 2,6-naphthylene ()), with release of (CH)SiCl as a volatile byproduct, afforded novel hybrid materials that feature Si-O-C bridges. The precursors and were characterized using FTIR and multinuclear (H, C, Si) NMR spectroscopy as well as single-crystal X-ray diffraction analysis in case of . Pyridine-catalyzed and non-catalyzed transformations were performed in THF at room temperature and at 60 °C.
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