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Frailty is a common clinical syndrome associated with increased risks of morbidity, mortality and other adverse outcomes. It is often used by healthcare providers as a tool for estimating patients` condition and triaging for Intensive Care Unit (ICU) admission, as recommended by several national guidelines. This study aimed to evaluate the utility of observed frailty, a subjective clinical assessment by physicians, as an alternative to the validated Clinical Frailty Score (CFS) and Modified Frailty Index (MFI). Additionally, the study explored the association of these frailty scoring systems with 30 day mortality, mechanical ventilation duration, and ICU length of stay. This retrospective study analyzed 100 patients admitted to an ICU at a tertiary center between March 12 and April 30, 2019. Observed frailty was assessed on a 4-point scale by physicians at ICU admission. CFS (7-point scale) and MFI (11-point scale) were retrospectively calculated. Correlations between these frailty assessments and their relationships with clinical outcomes were examined. Observed frailty correlated moderately with the CFS (Spearman coefficient = 0.4, p < 0.001) but showed a weaker, non-significant correlation with the MFI (Spearman coefficient = 0.18, p = 0.07). Significant differences in 30 day survival were observed based on the 4-point observed frailty scale (p < 0.001). Subjective assessment of frailty using a 4-point scale by physicians at ICU admission correlates with the CFS and is significantly associated with 30 day mortality. This suggests that observed frailty may be a practical tool for clinical decision-making. Further prospective studies are required to validate its utility and prognostic implications.
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http://dx.doi.org/10.1007/s11739-025-03976-6 | DOI Listing |
Lancet Digit Health
September 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; NIHR Biomedical Research Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Background: New-onset atrial fibrillation, a condition associated with adverse outcomes in the short and long term, is common in patients admitted to intensive care units (ICUs). Identifying patients at high risk could inform trials of preventive interventions and help to target such interventions. We aimed to develop and externally validate a prediction model for new-onset atrial fibrillation in patients admitted to ICUs.
View Article and Find Full Text PDFJ Bras Pneumol
September 2025
. Santa Casa de Misericórdia de Mogi Mirim, Mogi Mirim (SP) Brasil.
Objective: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in older adults, particularly those with comorbidities. Despite its clinical impact, RSV remains underdiagnosed and underreported. We sought to assess the burden of RSV in older adults (≥ 60 years of age) in Brazil using national surveillance data for the 2022-2023 period.
View Article and Find Full Text PDFExpert Rev Respir Med
September 2025
Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA.
Introduction: Alcohol use disorder (AUD) represents a major public health issue that produces far-reaching physiological effects. AUD is an underappreciated, yet critical risk factor clinicians need to be aware of and screen for to integrate preventive and therapeutic strategies when dealing with pneumonia in this vulnerable population. This research paper investigates the link between AUD and pneumonia by examining both the elevated risk of lung infection and the intensified disease severity.
View Article and Find Full Text PDFJ Ultrasound Med
September 2025
Evandro Chagas Infectious Diseases National Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Objectives: The risk of major venous thromboembolism (VTE) among patients with COVID-19 is high but varies with disease severity. Estimate the incidence of lower extremity deep venous thrombosis (DVT) in critically ill hospitalized patients with COVID-19, validate the Wells score for DVT diagnosis, and determine patients' prognosis.
Methods: This was an observational follow-up study in the context of the diagnosis and prognosis of DVT.
South Afr J Crit Care
May 2025
Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa.
Background: Procalcitonin (PCT) is used in the diagnosis of sepsis. Its capability as a prognostic marker is unclear. The association between PCT and paediatric intensive care unit (PICU) outcomes has not been investigated in the South African setting.
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