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Background: Periprosthetic tibial fractures around a total knee replacement (TKR) remain challenging to manage, with little published information for guidance. The purpose of this study was to review the types, management techniques, and outcomes of periprosthetic tibial fractures in the largest series to date.
Methods: We identified 300 periprosthetic tibial fractures (285 patients) around a TKR (43% in primary TKRs and 57% in revision TKRs) sustained between 1996 and 2020. Fractures were classified according to Felix et al. as Type I (tibial plateau), Type II (adjacent to stem), Type III (distal to stem), or Type IV (tibial tubercle), with subtypes A (well-fixed component), B (loose component), and C (intraoperative fracture). Of the fractures in this study, 53% were Type I, 24% were Type II, 16% were Type III, and 8% were Type IV. A total of 46% of fractures occurred intraoperatively, and 54% of fractures occurred postoperatively (61% subtype A, 39% subtype B). The mean patient age at fracture was 67 years, and 64% of patients were female. The mean follow-up was 6 years.
Results: The intraoperative fracture incidence was 1.40% in revision TKRs and 0.10% in primary TKRs. Among intraoperative fractures, the 2-year survivorship free from tibial component revision was highest in Type I (100%) and lowest in Type IV (67%) (p < 0.001). For postoperative fractures, the 2-year survivorship free from any reoperation was 29% and the 2-year survivorship free from tibial component revision was 51%. Type-I postoperative fractures had the lowest 2-year survivorship free from tibial component revision (10%), whereas Type-III fractures had the highest survivorship (88%) (p < 0.001).
Conclusions: Intraoperative periprosthetic fracture of the tibia was fourteenfold more likely in revision TKRs compared with primary TKRs. Among all intraoperative fractures, Type-I fractures were well-tolerated, with 100% survivorship free from tibial component revision at 2 years. Conversely, Type-I postoperative fractures had only 10% survivorship at 2 years.
Level Of Evidence: Therapeutic Level III . See Instructions for Authors for a complete description of levels of evidence.
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http://dx.doi.org/10.2106/JBJS.24.01407 | DOI Listing |
Am J Pharm Educ
September 2025
Touro College of Pharmacy, New York, NY.
Cancer rates are on the rise and new treatments are helping people live longer with cancer, yet the questions remains: when does one consider themselves a cancer survivor and what direction does one's career need to take when diagnosed with cancer? This commentary explores how mentoring can support working individuals, such as pharmacy faculty and staff, across the three distinct phases of cancer survivorship, (1) the acute phase including testing, diagnosis, staging, and treatment; (2) the post-treatment survival phase; and (3) the permanent phase of disease-free survival. While career mentoring programs may exist for pharmacy faculty and staff across various pharmacy practice settings, there is a notable lack of structured mentoring programs available for those faculty and staff navigating a cancer diagnosis, especially as mentoring needs shift throughout these three cancer survivorship phases. Thoughtful mentoring and support can significantly enhance the personal and professional quality of life for individuals with cancer.
View Article and Find Full Text PDFTher Adv Med Oncol
August 2025
Department of Medical Oncology, Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, Turkey.
Background: Metastatic gastric cancer (GC) and gastroesophageal junction (GEJ) cancer are associated with a poor prognosis. Recent advancements in treatment have incorporated trastuzumab, anti-PD-1 agents, and anti-claudin therapies alongside chemotherapy (ChT), significantly improving outcomes. Contemporary studies predominantly employ doublet ChT as the backbone for these regimens, although historically triplet ChT regimens have been favored, particularly in younger patients requiring rapid tumor shrinkage.
View Article and Find Full Text PDFInt Orthop
September 2025
Department of Orthopedic Surgery, Kangbuk Samsung Hospital, Seoul, Korea, Republic of.
Background: Multiple epiphyseal dysplasia (MED) is an inherited condition characterized by delayed and irregular ossification of the epiphyses that can lead to premature osteoarthritis. This study aimed to report the long-term outcomes of total hip arthroplasty (THA) in patients with MED.
Methods: We reviewed THAs performed in MED patients at a single institution between April 1997 and May 2014.
Curr Oncol
August 2025
Antalya Training and Research Hospital Medical Oncology Department, Antalya 07100, Turkey.
Unlabelled: The optimal sequencing of chemotherapy in locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare survival outcomes between adjuvant (ACT) and neoadjuvant (NACT) chemotherapy and to identify clinicopathological factors associated with progression-free survival (PFS) and overall survival (OS) in a real-world setting.
Methods: We retrospectively analyzed 103 patients with non-metastatic gastric cancer treated between 2014 and 2024.
J Dent Child (Chic)
May 2025
Professor and Head, Division of Pediatric and Preventive Dentistry, India Institute of Medical Sciences (AIIMS), New Delhi India.
Several studies have evaluated the effects of cancer-related chemo-radiation on developing teeth, leading to disturbances in the formation of enamel and dentin, affecting the crown and root. However, their impact on dental pulp has not been well explored. The purpose of this study was to evaluate dental pulp calcification among young cancer survivors.
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