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Article Abstract
The construction of C(sp)-C(sp) bonds through cross-coupling reactions of unactivated alkyl halides and C-radical precursors presents a significant challenge in organic synthesis. Herein, we report a strategy for the formation of C(sp)-C(sp) bonds using alkyl halides as alkylation reagents via the 1,5-hydrogen atom transfer (HAT) process. The reactions proceed under mild conditions, demonstrating a remarkable tolerance for a diverse array of functional groups. This method possesses the potential to expand new pathways in organic synthesis.
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| http://dx.doi.org/10.1021/acs.joc.5c00572 | DOI Listing |
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