98%
921
2 minutes
20
Biosensors are essential tools for detecting and analyzing various elements of human biology. This study introduces an innovative circular-shaped photonic crystal fiber (PCF) with a hexahedron core for the precise detection of blood components. The sensor's performance evaluated using COMSOL Multiphysics software. The finite element methods (FEM) is applied to solve Maxwell's equations and perform simulations across a terahertz (THz) frequency range from 1.0 to 3.0 THz. This comprehensive investigation focuses on optimizing several important optical parameters, including relative sensitivity (RS), confinement loss (CL), effective mode area (EMA), and birefringence, etc. for enhancing the detection of various blood components. The Optical sensor is constructed by Topas as cladding material. The sensor demonstrates exceptional performance with RS of approximately 95.02% for glucose, 95.48% for plasma, 96.30% for white blood cells (WBCs), and 97.04% for red blood cells (RBCs) at an operational frequency of 2.20 THz. Thus the proposed sensor can provide reliable and accurate measurements across different blood components in advanced biomedical applications.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1007/s12010-025-05274-5 | DOI Listing |
ACS Appl Mater Interfaces
September 2025
School of Integrated Circuits, Shandong University, Jinan 250100, P. R. China.
Transient electronics that can degrade after fulfilling their designed functionalities offer transformative potentials in biomedical implants (eliminating secondary surgeries), ecofriendly consumer electronics (reducing e-waste), and secure systems. However, the development of reliable transient energy supplies remains a critical challenge, thus limiting their widespread implementation. Among various solutions, wireless power supplies via near-field inductive coupling stand out as particularly promising candidates.
View Article and Find Full Text PDFCell Tissue Res
September 2025
Grupo de Investigaciones Biológicas y Moleculares (GIByM), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA NEA), Universidad Nacional del Nordeste (UNNE)-CONICET, Corrientes, Argentina.
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a crucial process in both physiological and pathological contexts, including cancer. Phospholipases A (PLAs), enzymes found in snake venoms, have attracted attention due to their potential antiangiogenic properties. In this study, we explored the antiangiogenic effects of PLA isoforms isolated from Bothrops diporus venom using a combination of in vivo and ex vivo models.
View Article and Find Full Text PDFArch Toxicol
September 2025
Laboratorio de Proteómica, Facultad de Microbiología, Instituto Clodomiro Picado, Universidad de Costa Rica, San José, 11501, Costa Rica.
The scorpion Hottentotta judaicus inhabits the Levant region of the Middle East, including Lebanon, Jordan, Palestine, and Israel. While previous research focused on its insecticidal properties and sodium-channel-targeting toxins, its venom remains largely unexplored using modern proteomic approaches. We analyzed the venom composition of H.
View Article and Find Full Text PDFAnal Chem
September 2025
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, P. R. China.
Electroactive bacteria (EAB) hold great promise for the development of electrochemical biosensors given their unique ability to transfer electrons extracellularly via specialized pathways, a process termed extracellular electron transfer (EET). Ongoing research aims to overcome current limitations and fully harness the potential of EABs for high-performance biosensing applications. Herein, we report the fabrication of an electrochemical microsensor based on biomineralized electroactive bacteria, specifically MR-1.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, United States.
Purpose: To assess macular choriocapillaris (CC) metrics in healthy volunteers (HVs) without ocular disease and demonstrate CC variations in patients with inherited retinal dystrophies (IRDs) using adaptive optics optical coherence tomography angiography (AO-OCTA).
Methods: Twenty-one HVs and three IRD patients were imaged. Macular variation in 20 HVs in CC metrics (CC density, CC diameter, CC tortuosity, void diameter, void area, lobule count, lobule area, and RPE-CC distance) were assessed by imaging a 28° strip of overlapping AO-OCTA volumes (3° × 3°) from the optic nerve head to the temporal macula.