Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: The prognostic accuracy of the American Joint Committee on Cancer (AJCC) 8th staging system for hypopharyngeal cancer remains uncertain. We aim to assess its survival prediction accuracy and compare it with the 7th edition.
Study Design: Retrospective investigation of prospective data.
Setting: Single-institution tertiary referral center.
Methods: A cohort of 200 patients with hypopharyngeal squamous cell carcinoma who underwent surgical intervention as primary treatment between 2007 and 2019 was analyzed. We evaluated overall survival (OS) and disease-specific survival (DSS) using the Kaplan-Meier method and the log-rank test for each AJCC edition. The Akaike information criterion (AIC) was used to assess prognostic prediction performance.
Results: The median follow-up was 67 months (29-100 months). In total, 93% of the patients (N = 186) underwent at least one side of neck dissection. In total, 41% of patients (N = 82) were upstaged as per the AJCC 8th, all resulting from the redistribution of N stage. Survival curves for DSS were better distinguished for stages I, II, and IVb in the AJCC 8th edition, yet an overlap was observed between stages III and IVa. The combination of extranodal extension (ENE) and cervical metastasis level well-differentiated the survival curves for OS and DSS. The AJCC 8th system outperformed the 7th, with lower AIC values for OS (1092 vs 1098) and DSS (654 vs 666).
Conclusion: The AJCC 8th edition improves survival prediction in hypopharyngeal cancer compared to the 7th, especially with the inclusion of ENE status and nodal metastasis classification revisions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ohn.1311 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of a new TNM staging system for poorly differentiated thyroid carcinoma: a multicenter cohort study.
Front Endocrinol (Lausanne)
September 2025
Department of General Surgery (Thyroid Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Objective: Poorly differentiated thyroid cancer (PDTC) is a rare, heterogeneous carcinoma from follicular cells, characterized by poor differentiation, aggressive spread, and poor prognosis. Currently, there is no specific staging system for PDTC. This study aimed to develop a new TNM staging system tailored to PDTC for improved disease management.
View Article and Find Full Text PDFPreoperative serum inflammatory markers in the prognostic assessment of hepatocellular carcinoma resection in stages I/II.
Front Mol Biosci
August 2025
Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Background: Hepatocellular carcinoma (HCC) remains a global health challenge, with early-stage resection offering the best chance for improved outcomes. However, limitations of the TNM staging system highlight the need for additional prognostic tools. This study evaluates the prognostic value of preoperative serum inflammatory markers in patients with stage I/II HCC undergoing surgical resection.
View Article and Find Full Text PDFDevelopment and validation of a nomogram for predicting overall and cancer-specific survival in elderly patients (≥ 65 years) with epithelial ovarian cancer.
Eur J Med Res
September 2025
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, 110004, People's Republic of China.
Background: Current evidence indicates an uptick in both morbidity and mortality rates of epithelial ovarian cancer (EOC) among the elderly (65 year and older) over the past few years. To date, standardized treatment for elderly patients remains undeveloped. This study utilizes the Surveillance, Epidemiology, and End Results (SEER) database to extract relevant clinicopathological data and construct two nomograms aimed at predicting the prognosis of elderly (65 year and older) patients with EOC.
View Article and Find Full Text PDFConcept of Depth of Invasion can Improve Staging Performance in Patients with Resected Distal Cholangiocarcinoma: Validation of the American Joint Committee on Cancer Staging System.
Cancer Res Treat
August 2025
Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Purpose: The American Joint Committee on Cancer (AJCC) staging system for distal cholangiocarcinoma (dCC) has evolved significantly. However, the prognostic correlation of the newly proposed staging system remains unclear. Therefore, we aimed to compare the staging performance between AJCC 7th and 8th editions for dCC.
View Article and Find Full Text PDFPathological extranodal extension in head and neck cancer: A prognostic biomarker with therapeutic ramifications and diagnostic pitfalls.
Pathol Res Pract
October 2025
Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. Electronic address:
Extranodal extension (ENE), defined as the pathological spread of metastatic tumor cells beyond the lymph node capsule into adjacent soft tissues, represents a critical prognostic biomarker in head and neck squamous cell carcinoma (HNSCC). Its presence correlates with aggressive tumor biology, increased risk of locoregional recurrence, distant metastasis, and reduced survival, thereby influencing staging systems and therapeutic strategies. The 8th edition of the AJCC Cancer Staging Manual has formally incorporated ENE into nodal classification for select HNSCC subsites, with the 9th edition of UICC (2025) extending this to HPV-positive oropharyngeal carcinomas.
View Article and Find Full Text PDF