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The numerical simulation of biological processes with non-integer ordering is attracting an increasing amount of interest from scientists and academics. Traditional biological systems can be presented in a fixed order, but fractional-order derivative systems are not considered stable orders. When the fractional derivative has a non-fixed order, it becomes more useful for simulating real-world problems. In this paper, we aim to study the dynamics of a novel technique that we propose, implement, and use in a radiation model for the treatment of cancer. We present some intriguing results for the cancer treatment fractal fractional model in the context of this innovative operator. Research has been done on the cancer model in both qualitative and quantitative manners. The first and second derivatives of the Lyapunov function are used to analyze the stability of the cancer fractal fractional model. Using the linear growth theory, the existence of a unique solution has been derived under the FFM. Lagrangian-piece-wise interpolation has been used to obtain numerical results for various fractal-fractional operators. The fractal fractional model was used to simulate the treatment process of three patients. Different values of fractional order [Formula: see text], fractal dimension [Formula: see text], and other parameter values have been used to show the graphs. Additionally, we looked at how radiation changed both healthy cells and malignant cells over time. The study confirmed the effectiveness of radiation medicine against populations as well as the occurrence of the memory effect during [Formula: see text] and [Formula: see text] transitions from 1. A biological process requires fractal-fractional processes which provide superior modeling capabilities compared to traditional fractional operators as well as classical operators. This research brings novel significance through its implementation of fractal-fractional operators as they provide a superior approach to model cancer treatment processes by better representing biological system complexities. Standard modeling systems cannot reproduce both important memory dynamics together with non-local communication patterns which play essential roles in cancer development and treatment analysis. The implementation of fractal-fractional derivatives enables our model to produce a more realistic representation of cancer cell and healthy cell radiotherapy responses throughout time. Our study has upgraded theoretical cancer dynamic analysis and developed optimized treatment methods for customization purposes. Wider understanding of cancer cell reactions to treatments enables healthcare providers to adopt personalized strategies that produce superior recovery outcomes for their patients. The model acquires stability strength through Lyapunov functions analysis to create a solid scientific foundation in oncology research.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091799 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0320906 | PLOS |
World J Urol
September 2025
Bichat Claude Bernard Hospital, Public Assistance of Paris Hospitals, Paris, France.
Purpose: Screening and diagnosing ISUP ≥ 2 prostate cancer is challenging. This study aimed to determine whether canine detection could be beneficial addition to the ISUP ≥ 2 prostate cancer diagnostic protocol by creating a decision-making algorithm for men with suspected prostate cancer.
Methods: We conducted a prospective study at two urology institutions and a French veterinary school, including men with a suspicion of prostate cancer from November to April 2023, which were divided into two groups according to their prostate biopsy results.
PLoS One
September 2025
School of Computer Science, CHART Laboratory, University of Nottingham, Nottingham, United Kingdom.
Background And Objective: Male fertility assessment through sperm morphology analysis remains a critical component of reproductive health evaluation, as abnormal sperm morphology is strongly correlated with reduced fertility rates and poor assisted reproductive technology outcomes. Traditional manual analysis performed by embryologists is time-intensive, subjective, and prone to significant inter-observer variability, with studies reporting up to 40% disagreement between expert evaluators. This research presents a novel deep learning framework combining Convolutional Block Attention Module (CBAM) with ResNet50 architecture and advanced deep feature engineering (DFE) techniques for automated, objective sperm morphology classification.
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September 2025
Hunan Mingxiang Aviation Technology Co., Ltd., Changsha, Hunan, China.
Flexible spacecraft possess the ability to adapt to complex environments and use energy more efficiently, offering enhanced flexibility and stability in space missions, particularly in tasks with significant external disturbances such as deep space exploration and satellite attitude control. However, vibration suppression in flexible spacecraft remains a critical challenge. This study addresses the problem of vibration suppression in flexible spacecraft systems under external disturbances and input constraints.
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September 2025
Remiza AI, Poughkeepsie, New York, United States of America.
Background: Hybrid entertainment formats combining competitive and comedic elements present opportunities to investigate factors driving audience engagement. I analyzed Taskmaster UK (2015-2023), a BAFTA-winning comedy panel show where comedians compete in creative tasks judged by a host, to quantify relationships between scoring mechanics, performer characteristics, and viewer ratings.
Methods: I analyzed 154 episodes encompassing 917 tasks performed by 90 contestants, with audience reception measured through 32,607 IMDb votes.
PLoS Comput Biol
September 2025
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America.
Fanconi Anemia (FA) is a heritable syndrome characterized by DNA damage repair deficits, frequent malformations and a significantly elevated risk of bone marrow failure, leukemia, and mucosal head and neck squamous cell carcinomas (HNSCC). Hematopoietic stem cell gene therapy can prevent marrow failure and lower leukemia risk, but mucosal gene therapy to lower HNSCC risk remains untested. Major knowledge gaps include an incomplete understanding of how rapidly gene-corrected cellular lineages could spread through the oral epithelium, and which delivery parameters are critical for ensuring efficient gene correction.
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