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Background: This study evaluates the effectiveness of different methods to recruit patients with inflammatory bowel disease (IBD) into a randomized controlled trial (RCT).
Methods: 630 participants were recruited into a multicenter RCT using electronic medical record (EMR) bulk messaging, in-person study discussion with a clinician, or a hybrid method combining the above approaches.
Results: Bulk EMR messaging alone had the highest recruitment and response rates, required the least amount of time to implement, and incurred the lowest cost as compared to the in-person and hybrid recruitment methods.
Conclusions: Digital health technology can enhance the recruitment of patients with IBD into randomized controlled trials.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082830 | PMC |
http://dx.doi.org/10.1093/crocol/otaf033 | DOI Listing |
Nutr J
September 2025
Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, 412 96, Sweden.
Background: Avenanthramides (AVAs) and Avenacosides (AVEs) are unique to oats (Avena Sativa) and may serve as biomarkers of oat intake. However, information regarding their validity as food intake biomarkers is missing. We aimed to investigate critical validation parameters such as half-lives, dose-response, matrix effects, relative bioavailability under single dose, and in relation to the abundance of Feacalibacterium prausnitzii, and under repeated dosing, to understand the potential applications of AVAs and AVEs as biomarkers of oat intake.
View Article and Find Full Text PDFBMC Health Serv Res
September 2025
Institute of General Practice, Rostock University Medical Center, Doberaner Str. 142, Rostock, 18057, Germany.
Background: Post-viral syndromes, including long- and post-COVID, often lead to persistent symptoms such as fatigue and dyspnoea, affecting patients' daily lives and ability to work. The COVI-Care M-V trial examines whether interprofessional, patient-centred teleconsultations, initiated by general practitioners in cooperation with specialists, can help reduce symptom burden and improve care for patients.
Methods: To evaluate the effectiveness of the intervention under routine care conditions, a cluster-randomised controlled trial is being conducted.
J Neuroeng Rehabil
September 2025
Institute for Neuromodulation and Neurotechnology, University Hospital and University of Tübingen, 72076, Tübingen, Germany.
Innovative technology allows for personalization of stimulation frequency in dual-site deep brain stimulation (DBS), offering promise for challenging symptoms in advanced Parkinson's disease (PD), particularly freezing of gait (FoG). Early results suggest that combining standard subthalamic nucleus (STN) stimulation with substantia nigra pars reticulata (SNr) stimulation may improve FoG outcomes. However, patient response and the optimal SNr stimulation frequency vary.
View Article and Find Full Text PDFJ Nephrol
September 2025
Department of Cardiovascular Sciences, University of Leicester, John Walls' Renal Unit, University Hospitals of Leicester NHS Trust, Leicester, UK.
Background: Individuals with kidney failure experience elevated cardiovascular risk, potentially worsened by the presence of sleep disordered breathing. Despite this association, prevalence of sleep apnoea, and evidence for effective treatments are poorly understood in people with kidney failure. This review examines sleep apnoea prevalence, types of sleep apnoea, and treatment interventions in people with kidney failure receiving dialysis.
View Article and Find Full Text PDFInt J Colorectal Dis
September 2025
Internal Medicine Department, Mirwais Regional Hospital, Kandahar, Afghanistan.
Background: The primary treatment for colorectal cancer, which is very prevalent, is surgery. Anastomotic leaking poses a significant risk following surgery. Intestinal perfusion can be objectively and instantly assessed with indocyanine green fluorescence imaging, which may lower leakage rates and enhance surgical results.
View Article and Find Full Text PDF