Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Cyclodextrins (CDs) play a crucial role in pharmaceutical formulations due to their unique ability to form inclusion complexes with a wide range of lipophilic drugs. Ternary complexes comprising CD, water-soluble polymer, and drug molecule have emerged as promising multicomponent to the challenges associated with poorly water-soluble drugs. The addition of water-soluble polymer as a ternary component often reduces the amount of CD required to form an inclusion complex thereby decreasing formulation bulk and toxicity. This review outlines the physicochemical properties of CDs and the formation of their inclusion complexes, as well as methods to enhance the complexation efficiency of drug/CD complexes. Additionally, it explores the classification and mucoadhesive properties of water-soluble polymers, and their mechanisms of mucoadhesion on mucosal membranes. The presence of small amounts of water-soluble polymers has been demonstrated to synergistically improve the complexation efficiency of drug/CD complexes. Recent advancements in modified CD-polymer conjugates and the use of water-soluble polymers in CD-based formulations, and their applications across various routes of administration are discussed, highlighting the potential of these ternary complexes as innovative platforms for drug delivery and therapeutic applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2025.123539 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of In Vitro and Dissolution of Norvir Oral Powder: Relevance of a too Rapid Dissolution Test.
Turk J Pharm Sci
September 2025
University of Maryland, Department of Pharmaceutical Sciences, Baltimore, USA.
Objectives: Norvir oral powder [ritonavir (RTV)] employs polyvinylpyrrolidone/vinyl acetate as the polymer to formulate an amorphous solid dispersion. Its oral absolute bioavailability is 70% in the fasted state, and it has negative food effects. The aim of this study was to perform in vitro dissolution of Norvir powder and Wagner-Nelson deconvolution of data under fasted, moderate fat, and high fat conditions in order to elucidate the relevance of dissolution testing.
View Article and Find Full Text PDFOxygen-Tolerant, Red Light-Driven Controlled Synthesis of Easily Degradable and High Molecular Weight α-Lipoic Acid-Vinyl Copolymers.
Angew Chem Int Ed Engl
September 2025
Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA.
α-Lipoic acid (LA) has recently emerged as an attractive, inexpensive monomer for synthesizing degradable polymers via ring-opening of its 1,2-dithiolane, introducing easily cleavable disulfide linkages into polymer backbones. Reversible addition-fragmentation chain transfer (RAFT) copolymerization with vinyl monomers enables access to degradable poly(disulfide)s with controlled molecular weights. However, conventional thermal RAFT methods suffer from oxygen sensitivity, limited LA incorporation (<40 mol%), and modest degrees of polymerization (DP < 300).
View Article and Find Full Text PDFGum arabic in drug delivery systems: A route-specific overview and functional insights.
Carbohydr Polym
November 2025
Department of Pharmaceutical Analysis, SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra 400056, India. Electronic address:
Gum Arabic (GA), a naturally occurring polysaccharide, has emerged as a promising biomaterial for drug delivery systems (DDS) due to its high water solubility, emulsifying capacity, biocompatibility, and biodegradability. Its structural richness in arabinogalactan facilitates strong interactions with biomolecules, enabling the development of various drug formulations including hydrogels, nanoparticles, liposomes, and emulsions. GA-based DDS have demonstrated significant potential in enhancing the solubility of poorly water-soluble drugs, protecting bioactive compounds from degradation, and enabling sustained and controlled drug release.
View Article and Find Full Text PDFPreparation and Evaluation of Amorphous Solid Dispersion of Etoricoxib, Employing A Fast Approach for Polymer Selection.
Antiinflamm Antiallergy Agents Med Chem
September 2025
AISSMS College of Pharmacy, SPPU, Pune, India.
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage pain and inflammation but are associated with gastrointestinal and cardiovascular risks, especially with COX-2 inhibitors. Topical delivery systems offer a safer alternative by minimizing systemic exposure; however, poor solubility and limited skin penetration remain challenges. Enhancing solubility through solid dispersion and incorporating it into a gel formulation may improve permeability and therapeutic effectiveness, addressing the need for safer and more efficient topical NSAID delivery.
View Article and Find Full Text PDFScar-reducing ionically conductive chitosan bandage: Combining ionic and electrical stimulation for optimal wound healing.
Biomaterials
August 2025
Nebraska Translational Research Center (NTRC), Department of Growth and Development, College of Dentistry, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:
Large, complex wounds frequently exhibit suboptimal healing, leading to scarring and functional impairment. While bioactive materials and electrical stimulation (ES) show promise, their individual limitations call for novel approaches. This study investigates the combined effects of combining 4-aminopyridine (4AP) and electrical stimulation (ES) on human dermal fibroblasts (hDFBs) using a stable, ionically conductive (IC) chitosan-based scaffold for controlled drug delivery.
View Article and Find Full Text PDF