Palladium(II)-Catalyzed Desymmetrization of 2-Alkynylbenzoate-Tethered Cyclohexadienones for the Synthesis of Polycyclic Compounds.

Pd-catalyzed cascade cyclization of 2-alkynylbenzoate-tethered cyclohexadienone was developed for the single step synthesis of isocoumarin-fused dihydrochromenones. This highly atom economical method proceeds via 6- cyclization of -butyl benzoate with a tethered alkyne. By modulating the reaction solvent and metal catalyst, the methodology was diverted for the purposeful synthesis of either of the tetra-substituted alkenes.