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We report two cases of patients with refractory discoid lupus erythematosus (DLE) and dark skin phototypes who experienced progressive perifollicular repigmentation of depigmented lesions under anifrolumab therapy, with sustained improvement over 18 months. These observations highlight a potential novel effect of anifrolumab on cicatricial dyspigmentation in DLE. This effect may represent a valuable therapeutic option for DLE-related damage, particularly in patients with darker skin types.
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http://dx.doi.org/10.1177/09612033251345017 | DOI Listing |
Am J Dermatopathol
September 2025
Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India.
Diagnosing a case of patchy alopecia in the setting of lupus erythematosus (LE) can be clinically challenging. Of the various causes of LE-specific alopecias, lupus panniculitis of the scalp is rarely reported. A 40-year-old woman presented with a nonscarring patch of alopecia over the scalp.
View Article and Find Full Text PDFLupus
August 2025
Nephrology Department, Sahloul University Hospital, Sousse, Tunisia.
ObjectivesThe aim of this study was to compare the clinicopathological characteristics and outcomes of lupus nephritis (LN) between late-onset and early-onset systemic lupus erythematosus (SLE) patients.MethodsWe reviewed the clinical, serological and histological characteristics of all patients with LN admitted to our nephrology unit between 2007 and 2024. Our patients were divided into two groups according to their age at diagnosis: Early-onset SLE (younger than 50 years) and late-onset SLE (50 years or older).
View Article and Find Full Text PDFOphthalmic Plast Reconstr Surg
August 2025
Department of Ophthalmology, Ege University Faculty of Medicine, Izmir, Türkeiye.
The aim was to present the clinical characteristics of patients with eyelid involvement as an isolated ophthalmological manifestation of lupus erythematosus. Four of 5 patients had eyelid lesions due to systemic lupus erythematosus, while 1 had eyelid involvement secondary to discoid lupus erythematosus. In 3 patients, the initial manifestation was an isolated eyelid lesion, with no prior diagnosis of lupus.
View Article and Find Full Text PDFCureus
July 2025
Dermatology, Academy of Aesthetic Medicine, Sheffield, GBR.
Background: Melasma remains an important dermatological ailment affecting diverse types of skin across the world. Various treatment modalities are currently employed to control melasma; however, the ideal treatment remains elusive. Comparative data regarding the efficacy of intralesional tranexamic acid (TA) and ascorbic acid (AA) mesotherapy (MT) in the treatment of melasma in South Asian skin is sparse.
View Article and Find Full Text PDFBr J Dermatol
August 2025
Department of Dermatology and Allergy, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
Background: Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease (ISD) with various clinical subtypes. Though the pathogenesis is not yet fully understood T cell mediated autoimmunity and elevated levels of type 1 interferons are two major factors contributing to the development of cutaneous lesions. Type 1 interferons transduce their signal via TYK2.
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