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In an effort to mitigate the elevated rates of sexual abuse reported by transgender adults incarcerated in state prisons, Washington State Department of Corrections has implemented policies that prioritize gender self-identification over birth-registered sex when making housing decisions. This has resulted in the transfer of males to the Washington Corrections Center for Women along with reports of negative impacts on incarcerated females. Any policy problem of unknown magnitude requires formal data collection and analysis. Washington State law, including one known as House Bill 1956, obstructs this process by preventing public access to information needed to evaluate the outcomes of incarcerated males and females of diverse gender identities. The Centers for Disease Control and Prevention has issued steps to ensure a fair and transparent policy process. To understand population-specific outcomes after a policy's implementation, health authorities recommend that demographics inclusive of sex and gender be collected, analyzed, and made available to stakeholders. Recommendations to balance the safety of vulnerable groups in Washington State detention facilities may require the expertise of a dedicated policy organization to navigate the legal and ethical challenges introduced by the law.
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http://dx.doi.org/10.1089/jchc.24.10.0083 | DOI Listing |
J Proteome Res
September 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington 98195, United States.
Retinol binding protein 4 (RBP4), the circulating carrier of retinol, complexes with transthyretin (TTR) and is a potential biomarker of cardiometabolic disease. However, RBP4 quantitation relies on immunoassays and Western blots without retinol and TTR measurement. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous absolute quantitation of circulating RBP4 and TTR is critical to establishing their biomarker potential.
View Article and Find Full Text PDFJAMA Surg
September 2025
Department of Orthopedic Surgery, Washington University School of Medicine, St Louis, Missouri.
JAMA Netw Open
September 2025
Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla.
Importance: Janus kinase (JAK) inhibitors are highly effective medications for several immune-mediated inflammatory diseases (IMIDs). However, safety concerns have led to regulatory restrictions.
Objective: To compare the risk of adverse events with JAK inhibitors vs tumor necrosis factor (TNF) antagonists in patients with IMIDs in head-to-head comparative effectiveness studies.
JAMA Netw Open
September 2025
Critical Illness, Brain Dysfunction, and Survivorship Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Importance: Survivors of critical illness often have ongoing issues that affect functioning, including driving ability.
Objective: To examine whether intensive care unit (ICU) delirium is independently associated with long-term changes in driving behaviors.
Design, Setting, And Participants: This multicenter, longitudinal cohort study included 151 survivors of critical illness residing within 200 miles of Nashville, Tennessee.
JAMA Dermatol
September 2025
Department of Dermatology, University of Washington, Seattle.
Importance: Merkel cell carcinoma (MCC) is typically caused by the Merkel cell polyomavirus (MCPyV) and recurs in 40% of patients. Half of patients with MCC produce antibodies to MCPyV oncoproteins, the titers of which rise with disease recurrence and fall after successful treatment.
Objective: To assess the utility of MCPyV oncoprotein antibodies for early detection of first recurrence of MCC in a real-world clinical setting.