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Uncovering the MET-TRIB3-FOXO1 axis: A Novel Target in MET-driven Hepatocellular Carcinoma.
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Department of Gastroenterology, Ajou University School of Medicine; 164 Worldcup-ro, Yeongtong-gu, Suwon 16499, Republic of Korea.
Correspondence: Response to Editorial on "Uncovering the MET-TRIB3-FOXO1 axis: A Novel Target in MET-driven Hepatocellular Carcinoma".
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Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
MET promotes hepatocellular carcinoma development through the promotion of TRIB3-mediated FOXO1 degradation.
Clin Mol Hepatol
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Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background/aims: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and abnormal MET expression plays a crucial role in its progression. However, the specific pathogenic mechanisms of MET in HCC have yet to be fully elucidated. This study aimed to uncover the oncogenic mechanisms of MET in HCC and explore potential therapeutic implications.
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