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http://dx.doi.org/10.1016/j.brs.2025.05.010 | DOI Listing |
Mol Biol Rep
September 2025
Department of Pharmacology, Govt. College of Pharmacy, Rohru, Shimla, Himachal Pradesh, 171207, India.
Alzheimer's disease (AD) is the most common, complex, and untreatable form of dementia which is characterized by severe cognitive, motor, neuropsychiatric, and behavioural impairments. These symptoms severely reduce the quality of life for patients and impose a significant burden on caregivers. The existing therapies offer only symptomatic relief without addressing the underlying silent pathological progression.
View Article and Find Full Text PDFBr J Neurosurg
September 2025
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Introduction: Radiosurgery targeting the thalamus has long been used to treat refractory pain, with medial thalamotomy as a key approach. Traditionally, targeting relied on indirect methods based on anatomical atlases, which do not account for individual variations in brain connectivity. Recent advances in connectomic-guided stereotactic radiosurgery have improved precision in the treatment of movement disorders, but their application to pain management remains underexplored.
View Article and Find Full Text PDFCureus
August 2025
Neurological Surgery, Punjab Institute of Neurosciences, Lahore, PAK.
Parvovirus B19 (PVB19) is an infrequent, serious, yet treatable cause of infection in immunocompromised hosts. Neurological manifestations of PVB19 are encephalitis, encephalopathy, meningitis, cerebellar ataxia, transverse myelitis, stroke, and peripheral neuropathy. The objective is to identify the exact clinical and diagnostic features specific to parvovirus B19 encephalitis for the isolation and management of the pathology.
View Article and Find Full Text PDFIntroduction: Advances in neonatology, neonatal surgery, and extracorporeal membrane oxygenation (ECMO) have improved the prognosis of congenital diaphragmatic hernia (CDH). However, CDH survivors are at considerable risk of long-term neurological morbidity. Magnetic resonance imaging (MRI) abnormalities are reported in up to 84% of CDH-survivors but have only been rarely compared with neurodevelopmental outcomes.
View Article and Find Full Text PDFNeuroimage
September 2025
Developing Brain Institute, Children's National Hospital, Washington, D.C., USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences,
The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T-weighted brain images and MRS data were acquired in the cerebellum, right frontal lobe and basal ganglia.
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