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Background: This paper examines: (i) the acceptability of, and behavioural outcomes associated with, take-home fentanyl test strips (FTS), and (ii) support for, and preferences regarding, drug checking services among people who use heroin.
Methods: Data were obtained from 78 people who had used heroin in the past 6 months, recruited from treatment and harm reduction services in Sydney, Australia in 2020-21. Participants were provided with 10 BTNX Rapid Response™ single-use immunoassay FTS and surveyed 4 weeks later.
Results: Among those who completed the follow-up survey (n = 72), 81% (n = 58) had used at least one FTS by the time of follow-up (median 6 strips). Participants reported high confidence in their ability to use FTS at both baseline (immediately post training) and follow-up. Of those who self-reported a positive FTS result (n = 25), 48% (n = 12) reported using less than they otherwise would have or starting with a smaller amount, and 60% (n = 15) shared this information with peers and/or health professionals. Of those who used FTS and responded, 95% (n = 54/57) reported that they would continue using FTS if they were free to access, and 97% (n = 56/58) would recommend them to their peers. Among those who completed the follow-up survey, the majority (93%; n = 67) reported that they would like to be able to access a drug checking service, preferably via a supervised injecting facility or Needle and Syringe Program.
Conclusions: Acceptability of FTS and support for drug checking were high among our sample. Multi-instrument approaches to drug checking may form one component of an effective response to the emerging threat of illicitly manufactured synthetic opioids.
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http://dx.doi.org/10.1186/s12954-025-01205-z | DOI Listing |
PLoS One
September 2025
Catherine McAuley School of Nursing and Midwifery, University College Cork, Cork, Ireland.
Introduction: Melatonin supplements and melatonin receptor agonists are linked to reduced delirium in the Intensive Care Unit (ICU) which we hypothesised may affect the length of stay (LOS) in ICU or in hospital. In this review, we identified and critically appraised the literature on the effect of exogenous melatonin and melatonin receptor agonists on the ICU and/or hospital LOS among adults admitted to the ICU.
Methods: Six electronic databases and three trial registries were searched for randomised controlled trials (RCTs).
J Eval Clin Pract
September 2025
Department of Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Leipzig, Germany.
Rationale: Outcome studies have shown the benefits of inhalation consultations. Therefore, the service of inhalation consultations from pharmacists has been implemented in guidelines. Recently, this service became reimbursable for German community pharmacies.
View Article and Find Full Text PDFPLoS One
September 2025
Experimental Physics, Saarland University, Saarbrücken, Germany.
Cellular adhesion and contractility are essential for cell movement. In this study, we investigated the effects of actin stabilization on adhesion properties, contractility, and cell migration. For this, we used the recently synthesized actin stabilizer miuraenamide A (MiuA), which has been discussed as a more reliable alternative to the otherwise commonly used actin stabilizer jasplakinolide.
View Article and Find Full Text PDFBMJ Open Sport Exerc Med
September 2025
Servizio di Endocrinologia e Diabetologia, Repubblica e Cantone Ticino Ente Ospedaliero Cantonale, Bellinzona, TI, Switzerland.
Background: The use of continuous glucose monitors (CGM) in scuba diving for patients with type 1 diabetes (T1DM) shows potential but faces challenges related to accuracy. Previous research has highlighted the poor accuracy of the Dexcom G7 (DG7) in repetitive diving contexts. This study investigates the impact of calibration on the accuracy of DG7, providing valuable insights for patients and clinicians.
View Article and Find Full Text PDFJ Wound Care
September 2025
DEBx Medical B.V., Amsterdam, Netherlands.
Diabetic foot ulcers (DFUs) are a major complication of diabetes, often requiring effective wound bed preparation for healing. This retrospective case series assessed a novel topical desiccating agent (TDA) used under a compassionate-use protocol approved by the institutional ethics board. A total of 67 patients with hard-to-heal (chronic) DFUs treated between 2020 and 2023 were included.
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