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http://dx.doi.org/10.1245/s10434-025-17405-7 | DOI Listing |
Cancer Sci
August 2025
Department of Otolaryngology-Head and Neck Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
Head and neck cancers (HNCs) are a heterogeneous group of malignancies, including head and neck squamous cell carcinoma (HNSCC), thyroid carcinoma, and salivary gland carcinoma. Despite multidisciplinary treatment approaches, outcomes for advanced HNCs remain poor. Among these, HNSCC has been the most extensively studied in the field of immunotherapy.
View Article and Find Full Text PDFEpigenomics
August 2025
Epigenetics Research Laboratory, Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Breast cancer is one of the most commonly diagnosed cancers worldwide and is a significant contributor to the global cancer burden. It is a clinically heterogeneous disease and reliable tools are needed to support treatment decisions, including patient risk, prediction of therapeutic response and monitoring patients throughout their cancer journey. DNA methylation alterations are an early occurring, highly pervasive and stable modification during tumorigenesis, making DNA methylation an attractive target for the development of biomarkers.
View Article and Find Full Text PDFCurr Opin Endocrinol Diabetes Obes
October 2025
Monash University Endocrine Surgery Unit, Alfred Hospital.
Purpose Of Review: Whilst the prognosis of thyroid carcinoma remains excellent, patients with advanced thyroid carcinoma have a considerable burden of disease. Clinicians continue to face and manage challenging scenarios in the setting of thyroid cancer, particularly in those with recurrent disease, metastatic disease or special scenarios such as thyroid cancer in pregnancy. The purpose of this article is to provide an overview of thyroid cancer management and an update in emerging areas of management, particularly in the setting of locally advanced disease.
View Article and Find Full Text PDFAm Surg
August 2025
Hainan Medical University, Haikou, China.
Esophageal cancer is a malignancy of the digestive tract characterized by high aggressiveness and poor prognosis. The two main histological subtypes are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. Traditional treatment strategies for esophageal cancer include surgery, radiotherapy, and chemotherapy.
View Article and Find Full Text PDFCancer Radiother
September 2025
Institut Gustave-Roussy, 114, rue Édouard-Vaillant, 94805 Villejuif cedex, France. Electronic address:
This review aims to explore the radiobiological rationale and clinical evidence supporting the use of hypofractionated radiotherapy in the management of rectal tumours, particularly in neoadjuvant treatment strategies and organ preservation approaches. An overview of key randomized controlled trials on hypofractionated radiotherapy, also called short-course radiotherapy, was conducted. Clinical trials have demonstrated oncological equivalence between hypofractionated radiotherapy and standard long-course chemoradiotherapy in terms of overall survival and local recurrence, but short-course radiotherapy represents a relevant therapeutic option for frail or elderly patients.
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