Stereoselective Assembly of -Fluoroacrylate-Substituted -Lactams via Acid-Base Microenvironment-Controlled Carbonylation.

We developed a stereoselective synthesis strategy for -fluoroacrylate-substituted -lactams, utilizing an innovative acid-base synergistic regulation approach. This method employs a dioxane-mediated microreaction environment to spatially separate acidic and alkaline reagents, enabling precise control over cyclization and fluorination processes. This strategy enhances catalytic efficiency and addresses challenges in Pd-catalyzed reactions, offering a new paradigm for synthesizing fluorinated drug molecules amid acid-base complexities.