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Background: Ambiguity is inherent in medicine, and tolerance for ambiguity (TFA) has recently been of substantial interest. Effective medical education for TFA requires a validated inventory; one validated measure in wide use is the seven-item TFA scale. In Japan, however, a tool for measuring TFA in undergraduate medical education has not been available. Here, we aimed to develop and validate the Japanese version of the TFA scale (J-TFA scale).
Methods: We translated the original English scale into Japanese following an international guideline. We then conducted a validation survey by distributing an online anonymous self-administered questionnaire to medical students at three medical schools in Japan. We assessed the structural validity and internal reliability of consistency of the scale.
Results: A total of 399 participants were included in our analysis. We used a split-half validation approach, with exploratory factor analysis (EFA) on the first half and confirmatory factor analysis (CFA) on the second. EFA indicated a two-factor structure. CFA showed that the two-factor structure suggested by EFA had acceptable model fitness indices. Cronbach's alpha was 0.72, exceeding the satisfactory internal reliability consistency criteria.
Conclusions: The J-TFA scale was developed and its psychometric properties were confirmed. This instrument may be useful for future educational interventions and research on TFA.
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http://dx.doi.org/10.1007/s40670-024-02269-5 | DOI Listing |
Front Hum Neurosci
August 2025
Faculty of Human Sciences, Waseda University, Tokorozawa, Japan.
Suppressing irrelevant information during problem-solving is vital. Misleading or unrelated information may hinder the performance. However, previous studies inferred suppression-related brain regions based on overall problem-solving or pre-solution neural activity, resulting in insufficient experimental control over the precise timing of suppression and the types of information requiring suppression.
View Article and Find Full Text PDFAging Clin Exp Res
September 2025
Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Background: Intrinsic capacity (IC) and frailty are distinct but complementary frameworks for understanding the heterogeneity of aging. Although both have been linked to self-rated health, little is known about how their combined status relates to older adults’ health perceptions. This cross-sectional study investigated how combinations of IC and frailty status were associated with self-rated health among community-dwelling older adults.
View Article and Find Full Text PDFJ Dermatol
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Department of Dermatology, Shizuoka Cancer Center, Shizuoka, Japan.
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in patients with advanced malignant melanoma (MM). However, more than half of patients receiving anti-programmed cell death protein-1 (PD-1) antibody monotherapy still fail to respond, with response rates varying by race and melanoma subtype. Additionally, immune-related adverse events (irAEs) remain a major concern.
View Article and Find Full Text PDFDrugs Aging
September 2025
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Toho University (Ohashi Medical Center), Tokyo, Japan.
Interleukin (IL)-6 plays a central role in amplifying inflammation, and its inhibition is beneficial in managing immune-mediated inflammatory diseases (IMIDs) such as rheumatoid arthritis (RA). IL-6 signaling inhibition is associated with a slightly increased risk of infections in patients with RA, and older age has been identified as a risk factor for severe adverse events, including infections. Therefore, the combination of an aging population and the increasing use of IL-6R inhibitors in RA treatment highlights the importance of carefully evaluating the safety and effectiveness of these therapies in older patients with RA.
View Article and Find Full Text PDFAppl Neuropsychol Adult
September 2025
Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Tochigi, Japan.
Early detection is a critical issue in dementia prevention. This study utilizes intra-individual variability in reaction time (IIV-RT) as an indicator of cognitive function. By analyzing data over a one-year period, we examine the association between IIV-RT and the Japanese version of the Montreal Test of Cognitive Abilities (MoCA-J), a cognitive screening test.
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