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Article Abstract
This work reports the first synthesis of Δ-pyrrolines promoted by visible light under continuous flow, achieved through the formal (3 + 2)-cycloaddition of 2-azirines to enones. A total of 22 examples of trisubstituted Δ-pyrrolines were prepared in only 30 min of residence time, with 41-93% yield and diastereomeric ratios up to 7:3. Furthermore, continuous flow conditions were also effective when chalcones were used as starting materials, leading to the formation of 7 tetrasubstituted pyrroles with an overall yield ranging from 12 to 47%, via a photocatalyzed cycloaddition-oxidation sequence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060062 | PMC |
| http://dx.doi.org/10.1021/acsomega.5c01416 | DOI Listing |
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