Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Boosting an intracellular signaling pathway preserves the antidepressant response to ketamine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.adx4559 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors . Physiology seeks to elucidate the intricate network of interactions that sustain life, which often span multiple organs, cell types, and timescales, but a major challenge lies in the inability to simultaneously record time-varying cellular activity throughout the entire body. We developed WHOLISTIC, a method to image second-timescale, time-varying intracellular dynamics across cell-types of the vertebrate body.
View Article and Find Full Text PDFNeuraxial anesthesia and pain management for cesarean delivery.
Am J Obstet Gynecol
July 2025
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA.
Optimal neuraxial anesthesia for cesarean delivery requires a thorough understanding of patient, obstetrical, surgical, and anesthesia-related factors which can impact pain during and after cesarean delivery. While not all cesarean deliveries are the same from an obstetrical standpoint, not all anesthetics provide the same degree of anesthetic blockade and postcesarean analgesia; therefore, context is crucial to provide patients with a safe and pain-free experience. Communication between obstetrical and anesthesia teams is key to ensure that the anesthetic approach is tailored to the clinical scenario, particularly if emergency cesarean delivery is needed, and follows best practices for cesarean delivery anesthesia.
View Article and Find Full Text PDFReinforcing Gaps? A Rapid Review of Innovation in Borderline Personality Disorder (BPD) Treatment.
Brain Sci
July 2025
Health and Social Union for Support and Prevention (USSAP), 11300 Limoux, France.
: Borderline Personality Disorder (BPD) involves emotional dysregulation, interpersonal instability and impulsivity. Although treatments have advanced, evaluating the latest innovations remains essential. This rapid review aimed to (1) identify and classify recent therapeutic innovations for BPD, (2) assess their effects on clinical and functional outcomes, and (3) highlight research gaps to inform future priorities.
View Article and Find Full Text PDFA Preliminary Approach to Oral Low-Dose Ketamine Self-Administration in Mice ().
Curr Issues Mol Biol
July 2025
Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-Os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.
With ketamine gaining attention as a therapeutic drug, oral administration offers an effective alternative to traditional parenteral routes. However, a significant gap remains in understanding its use via voluntary ingestion. This preliminary study aimed to explore the feasibility of oral ketamine self-administration in mice (), while investigating the effects of low concentrations on the brain, liver, and kidney.
View Article and Find Full Text PDFAll roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants.
Pharmacol Res
August 2025
Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Frankfurt, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, Frankfurt am Main 60596, Germany.
Treatment-resistant depression (TRD) represents a major clinical challenge. Affecting about 30 % of major depressive disorder (MDD) patients, effective treatments for TRD are urgently needed. While depression research and antidepressant (AD) development have long centred on monoaminergic targets, research over the past 35 years has increasingly explored glutamatergic mechanisms.
View Article and Find Full Text PDF