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http://dx.doi.org/10.2459/JCM.0000000000001724 | DOI Listing |
Anal Biochem
September 2025
College of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
This study aimed to investigate potential biomarkers related to Endoplasmic reticulum (ER) stress in Amyotrophic lateral sclerosis (ALS) through a comprehensive bioinformatic approach. The gene expression profiles of ALS patients and healthy controls were downloaded from the Gene Expression Omnibus (GEO) database. ER stress-related genes were collected from the MSigDB databases and document literature.
View Article and Find Full Text PDFJ Ayurveda Integr Med
September 2025
Regional Ayurveda Research Institute, Poojappura, Thiruvananthapuram, Kerala, 695012, India; Under Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, New Delhi, India.
This case report is the description of a devastating illness, Progressive Bulbar Palsy (PBP) of a sixty-seven years old male patient. He presented with complaints of slurred speech, hearing impairment, generalised weakness of limbs, weakened grip to hold objects in hand, difficulty to walk with normal speed, frequent dizzy feeling while walking, severe fatigue, increased anger, heaviness of head, depression, anxiety, decreased memory and headache for 1 year. When he consulted conventional medicine, in Magnetic Resonance Imaging (MRI) of brain, only 'Partial empty sella' and age related mild cerebral atrophy was detected and the patient was diagnosed PBP clinically.
View Article and Find Full Text PDFBMJ Case Rep
September 2025
Department of Neurology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA.
Monomelic amyotrophy (MMA) is a lower motor neuron predominant disorder affecting an upper limb, which can mimic amyotrophic lateral sclerosis (ALS). It often presents with unilateral, distal upper limb weakness and atrophy, whose trajectory is one of an initial period of progression followed by a prolonged plateau, as opposed to the typically relentless progression as is seen in ALS. This case report describes a novel observation of a patient with MMA with an unexplained ipsilateral partial Horner's syndrome (miosis and ptosis).
View Article and Find Full Text PDFNeurobiol Dis
September 2025
Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.
TDP-43 is known to bind the mRNA of histone deacetylase 6 (HDAC6), influencing its RNA translation. Many studies suggest that HDAC6 participates in the regulation of autophagy, which we found impaired in sporadic ALS (sALS) patients. Aim of this work is to evaluate the interaction between TDP-43 and HDAC6 mRNA and to evaluate the effect of the up- and down-regulation of HDAC6 on autophagy in SH-SY5Y cells.
View Article and Find Full Text PDFRespir Care
September 2025
Ms. Vieira, Dr. Lima, Dr. Pondofe, Ms. Maciel, Dr. da Fonsêca, Dr. Resqueti, and Dr. Fregonezi, are affiliated with the Departamento de Fisioterapia, PneumoCardioVascular Lab/HUOL and the Laboratório de Inovação Tecnológica em Reabilitação, Universidade Federal do Rio Grande do Norte, Natal,
Mechanical insufflation-exsufflation (MI-E) consists of increasing expiratory air flow, thereby promoting an increase in cough peak flow (CPF) and secretion clearance. Respiratory impairment, characterized by reduced lung volumes and ineffective cough, is the major cause of morbidity and mortality in patients with amyotrophic lateral sclerosis (ALS). This study aimed to assess the acute effects of MI-E on CPF and chest wall compartmental and operational volumes in patients with ALS.
View Article and Find Full Text PDF