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Objective: This study aims to identify key contributing factors to driver ejection in vehicle crashes. By analyzing crash characteristics, restraint usage, and environmental conditions, the study provides data-driven insights to mitigate ejection risks and improve roadway safety interventions.
Method: This study, utilizing comprehensive Texas crash data from 2017 to 2022; investigates this critical concern by applying an ARM algorithm to uncover key patterns and interactions among various factors contributing to ejection events. By analyzing the specific circumstances under which driver ejections occur, both with and without restraint usage, the study examines the dynamics of these crashes and their contributing factors.
Results: The analysis reveals that most fatal and severe ejection crashes involving restrained drivers are strongly associated with vehicle overturns, compounded by the interaction of dark lighting conditions, curved road segments, high posted speed limits (70 mph or higher), and two-lane, two-way rural roads. In contrast, ejection crashes involving unrestrained drivers are predominantly linked to dark lighting conditions, rural two-lane roads, and pickup or SUV-type vehicles, where the absence of restraint significantly increases the risk of fatal or severe injuries. Airbag deployment status, particularly cases of non-deployment or multiple deployments, has been observed in combination with other crash factors, such as high-speed impacts and overturning, contributing to an increased likelihood of ejection.
Conclusions: These findings suggest targeted safety solutions including better roadway lighting and guardrails to reduce overturning-induced ejections, stricter rural seatbelt enforcement, and enhanced vehicle restraint systems to limit unintentional occupant movement.
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http://dx.doi.org/10.1080/15389588.2025.2491580 | DOI Listing |
J Chem Theory Comput
September 2025
Exscientia plc, Schrodinger Building, Oxford OX4 4GE, U.K.
Protein-ligand binding affinity prediction is a key aspect in computational small molecule drug discovery. Several recent studies have demonstrated that molecular simulations based on alchemical absolute binding free-energy (ABFE) calculations are an accurate and broadly applicable tool for this purpose. However, the use of current ABFE protocols in large scale drug discovery projects occasionally leads to unstable simulations and poor convergence.
View Article and Find Full Text PDFInfect Dis Model
December 2025
School of Veterinary Medicine Department of Medicine and Epidemiology, University of California, Davis, CA, USA.
We explored a compartment "susceptible-infected-recovered" model to prioritize and test the effectiveness of dog- and tick-based interventions against Rocky Mountain spotted fever and its tick vector s.l. In the face of increasingly urban epidemics of RMSF with high case fatality, particularly targeting marginalized communities, wrap-around campaigns (comprising all or some of canine culling, fertility control, and restraint to property; on-dog and environmental acaricide; and education and awareness programs for public health workers and at-risk residents) are unsustainably resource-intensive and may lack efficacy in managing the very hard to control tick.
View Article and Find Full Text PDFClin Pract
June 2025
Western Health, Melbourne 3021, Australia.
: The administration of parenteral medications is essential in managing acute arousal within the Behavioral Assessment Unit (BAU) of the emergency department (ED), where timely and effective intervention is critical. This study aims to evaluate current practices surrounding the use of parenteral medications for patients with acute agitation, focusing on adherence to protocols, medication safety, documentation accuracy, and patient outcomes. : A retrospective analysis was conducted on 177 cases from December 2023 to February 2024.
View Article and Find Full Text PDFJ Pharmacol Toxicol Methods
June 2025
Amgen Research, Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA 91320, USA.. Electronic address:
Introduction: Cardiovascular (CV) parameters such as blood pressure (BP), electrocardiogram (ECG), and heart rate (HR) are recorded in non-rodent non-clinical safety studies to support drug development. However, measurement quality varies depending on the methodology used, including restraint-based or telemetry (implanted or jacketed) techniques. Measurement quality, in this context, refers to the sensitivity and reliability of CV measurements in affecting baseline values of measured CV parameters and in detecting pharmacological effects.
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